DNA-protective activities of hyperforin and aristoforin

•Mechanisms of hyperforin and aristoforin DNA-protective activities were studied in vitro.•Both chemicals protect DNA against Fe2+-induced DNA breaks.•Mechanism of DNA protection is based on their activity to scavenge free radicals, mainly OH.•Hyperforin and aristoforin are not able to inhibit topoi...

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Veröffentlicht in:	Toxicology in vitro 2015-04, Vol.29 (3), p.631-637
Hauptverfasser:	Ševčovičová, A., Šemeláková, M., Plšíková, J., Loderer, D., Imreová, P., Gálová, E., Kožurková, M., Miadoková, E., Fedoročko, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Aristoforin DNA - drug effects DNA Breaks - drug effects DNA unwinding assay DNA-topology assay DPPH[rad]/[rad]OH scavenging activity Free Radical Scavengers - pharmacology Hyperforin Hypericum - chemistry Hypericum perforatum Iron - toxicity Iron Chelating Agents - pharmacology Phloroglucinol - analogs & derivatives Phloroglucinol - pharmacology Reducing power assay Terpenes - pharmacology Topoisomerase I Inhibitors - pharmacology
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