RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma

Male predominance of hepatocellular carcinoma (HCC) occurs particularly among young children aged 6‐9 years, indicative of a possible role of the Y chromosome–encoded oncogene in addition to an androgenic effect. The discovery of oncogenic activation of RBMY (RNA‐binding motif on Y chromosome), whic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2015-11, Vol.62 (5), p.1480-1496
Hauptverfasser:	Chua, Huey‐Huey, Tsuei, Daw‐Jen, Lee, Po‐Huang, Jeng, Yung‐Ming, Lu, Jean, Wu, Jia‐Feng, Su, De‐Shiuan, Chen, Ya‐Hui, Chien, Chin‐Sung, Kao, Pei‐Chi, Lee, Chien‐Nan, Hu, Rey‐Heng, Ni, Yen‐Hsuan, Chang, Mei‐Hwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals beta Catenin - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Female Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 beta Humans Infant Liver Neoplasms - drug therapy Liver Neoplasms - mortality Liver Neoplasms - pathology Male Middle Aged Nuclear Export Signals Nuclear Proteins - physiology Phosphorylation Prognosis Protein Stability Rats RNA-Binding Proteins - physiology Wnt3A Protein - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!