GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice
Problem Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP‐1 receptor (GLP‐1R) agonist exenatide on sperm quality in high‐fat diet (HFD)‐induced obese mice. Method of study After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to eit...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2015-11, Vol.74 (5), p.457-466 |
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| container_end_page | 466 |
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| container_issue | 5 |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 74 |
| creator | Zhang, Erhong Xu, Fen Liang, Hua Yan, Jinhua Xu, Haixia Li, Zhuo Wen, Xingqiao Weng, Jianping |
| description | Problem
Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP‐1 receptor (GLP‐1R) agonist exenatide on sperm quality in high‐fat diet (HFD)‐induced obese mice.
Method of study
After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to either saline or exenatide (24 nmol/kg/day) interventions for 8 weeks. Sperm quality and the inflammatory profile of testis were compared among three groups.
Results
Obesity reduced the quality of sperm and changed the inflammatory profile characterized by increased mRNA expression levels of TNF‐α, MCP‐1, and F4/80 in testis. Exenatide intervention reduced the expression of pro‐inflammatory cytokines and improved the quality of sperm.
Conclusion
HFD‐induced obesity leads to the impairment of sperm quality and increased inflammation of testis in mice, and the abnormal physiology can be attenuated by exenatide treatment. Exenatide treatment may bring additional profits to obese and diabetes men by improving sperm function. |
| doi_str_mv | 10.1111/aji.12420 |
| format | Article |
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Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP‐1 receptor (GLP‐1R) agonist exenatide on sperm quality in high‐fat diet (HFD)‐induced obese mice.
Method of study
After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to either saline or exenatide (24 nmol/kg/day) interventions for 8 weeks. Sperm quality and the inflammatory profile of testis were compared among three groups.
Results
Obesity reduced the quality of sperm and changed the inflammatory profile characterized by increased mRNA expression levels of TNF‐α, MCP‐1, and F4/80 in testis. Exenatide intervention reduced the expression of pro‐inflammatory cytokines and improved the quality of sperm.
Conclusion
HFD‐induced obesity leads to the impairment of sperm quality and increased inflammation of testis in mice, and the abnormal physiology can be attenuated by exenatide treatment. Exenatide treatment may bring additional profits to obese and diabetes men by improving sperm function.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12420</identifier><identifier>PMID: 26287267</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Animals ; Cytokines - metabolism ; Diet, High-Fat ; Fertility ; GLP-1 ; Glucagon-Like Peptide-1 Receptor - agonists ; Incretins - pharmacology ; inflammation ; Inflammation - metabolism ; Male ; Mice ; obesity ; Obesity - metabolism ; Peptides - pharmacology ; sperm quality ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Testis - drug effects ; Testis - metabolism ; Venoms - pharmacology</subject><ispartof>American journal of reproductive immunology (1989), 2015-11, Vol.74 (5), p.457-466</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5950-9321c90cd5f801dc7b5ea67e6cd4d3ebca9baaedde94fccb93857ad0906464663</citedby><cites>FETCH-LOGICAL-c5950-9321c90cd5f801dc7b5ea67e6cd4d3ebca9baaedde94fccb93857ad0906464663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.12420$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.12420$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26287267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Erhong</creatorcontrib><creatorcontrib>Xu, Fen</creatorcontrib><creatorcontrib>Liang, Hua</creatorcontrib><creatorcontrib>Yan, Jinhua</creatorcontrib><creatorcontrib>Xu, Haixia</creatorcontrib><creatorcontrib>Li, Zhuo</creatorcontrib><creatorcontrib>Wen, Xingqiao</creatorcontrib><creatorcontrib>Weng, Jianping</creatorcontrib><title>GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP‐1 receptor (GLP‐1R) agonist exenatide on sperm quality in high‐fat diet (HFD)‐induced obese mice.
Method of study
After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to either saline or exenatide (24 nmol/kg/day) interventions for 8 weeks. Sperm quality and the inflammatory profile of testis were compared among three groups.
Results
Obesity reduced the quality of sperm and changed the inflammatory profile characterized by increased mRNA expression levels of TNF‐α, MCP‐1, and F4/80 in testis. Exenatide intervention reduced the expression of pro‐inflammatory cytokines and improved the quality of sperm.
Conclusion
HFD‐induced obesity leads to the impairment of sperm quality and increased inflammation of testis in mice, and the abnormal physiology can be attenuated by exenatide treatment. Exenatide treatment may bring additional profits to obese and diabetes men by improving sperm function.</description><subject>Animals</subject><subject>Cytokines - metabolism</subject><subject>Diet, High-Fat</subject><subject>Fertility</subject><subject>GLP-1</subject><subject>Glucagon-Like Peptide-1 Receptor - agonists</subject><subject>Incretins - pharmacology</subject><subject>inflammation</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>obesity</subject><subject>Obesity - metabolism</subject><subject>Peptides - pharmacology</subject><subject>sperm quality</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - metabolism</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Venoms - pharmacology</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1vFCEUhidGYz_0wj9gSLzRi2lhPmC43Nbtds32y9b0kjBwRllnYAUmdv-Cv7qs2_bCxKRwwQGe8wbeN8veEXxA0jiUS3NAiqrAL7JdQjHOccPZy1Tjiuasws1OthfCEuN0XrLX2U5Bi4YVlO1mf2aLy5ygr6BgFZ1Hk-_OmhDR9A6sjEYDmsQIdpQRAoo_AH2G6M0ANsoeTbsOVAzIdeiihWDiGjmL5rbr5TDIJLdGl951pgdkLLqBEE1A0mp0vQI_oKtR9puedHdmFLzJXnWyD_D2Yd3Pvp1Mb45P88XFbH48WeSq5jXOeVkQxbHSdddgohVra5CUAVW60iW0SvJWStAaeNUp1fKyqZnUmGNapUnL_ezjVnfl3a8xPUoMJijoe2nBjUEQVjDKaU2q56Ab24uSJ_TDP-jSjd6mj2wo0tC6LppEfdpSyrsQPHRildyUfi0IFpssRcpS_M0yse8fFMd2AP1EPoaXgMMt8Ds5vP6_kph8mT9K5tuOFDHcPXVI_1MkPVaL2_OZOJpd39Lzs7Qp7wG4Dbew</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Zhang, Erhong</creator><creator>Xu, Fen</creator><creator>Liang, Hua</creator><creator>Yan, Jinhua</creator><creator>Xu, Haixia</creator><creator>Li, Zhuo</creator><creator>Wen, Xingqiao</creator><creator>Weng, Jianping</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice</title><author>Zhang, Erhong ; Xu, Fen ; Liang, Hua ; Yan, Jinhua ; Xu, Haixia ; Li, Zhuo ; Wen, Xingqiao ; Weng, Jianping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5950-9321c90cd5f801dc7b5ea67e6cd4d3ebca9baaedde94fccb93857ad0906464663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cytokines - metabolism</topic><topic>Diet, High-Fat</topic><topic>Fertility</topic><topic>GLP-1</topic><topic>Glucagon-Like Peptide-1 Receptor - agonists</topic><topic>Incretins - pharmacology</topic><topic>inflammation</topic><topic>Inflammation - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>obesity</topic><topic>Obesity - metabolism</topic><topic>Peptides - pharmacology</topic><topic>sperm quality</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - metabolism</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Venoms - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Erhong</creatorcontrib><creatorcontrib>Xu, Fen</creatorcontrib><creatorcontrib>Liang, Hua</creatorcontrib><creatorcontrib>Yan, Jinhua</creatorcontrib><creatorcontrib>Xu, Haixia</creatorcontrib><creatorcontrib>Li, Zhuo</creatorcontrib><creatorcontrib>Wen, Xingqiao</creatorcontrib><creatorcontrib>Weng, Jianping</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Erhong</au><au>Xu, Fen</au><au>Liang, Hua</au><au>Yan, Jinhua</au><au>Xu, Haixia</au><au>Li, Zhuo</au><au>Wen, Xingqiao</au><au>Weng, Jianping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>74</volume><issue>5</issue><spage>457</spage><epage>466</epage><pages>457-466</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP‐1 receptor (GLP‐1R) agonist exenatide on sperm quality in high‐fat diet (HFD)‐induced obese mice.
Method of study
After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to either saline or exenatide (24 nmol/kg/day) interventions for 8 weeks. Sperm quality and the inflammatory profile of testis were compared among three groups.
Results
Obesity reduced the quality of sperm and changed the inflammatory profile characterized by increased mRNA expression levels of TNF‐α, MCP‐1, and F4/80 in testis. Exenatide intervention reduced the expression of pro‐inflammatory cytokines and improved the quality of sperm.
Conclusion
HFD‐induced obesity leads to the impairment of sperm quality and increased inflammation of testis in mice, and the abnormal physiology can be attenuated by exenatide treatment. Exenatide treatment may bring additional profits to obese and diabetes men by improving sperm function.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>26287267</pmid><doi>10.1111/aji.12420</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2015-11, Vol.74 (5), p.457-466 |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1727696514 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Cytokines - metabolism Diet, High-Fat Fertility GLP-1 Glucagon-Like Peptide-1 Receptor - agonists Incretins - pharmacology inflammation Inflammation - metabolism Male Mice obesity Obesity - metabolism Peptides - pharmacology sperm quality Spermatozoa - drug effects Spermatozoa - metabolism Testis - drug effects Testis - metabolism Venoms - pharmacology |
| title | GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice |
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