Proteomic Study of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome in Rats

Pyrrolizidine alkaloids (PAs) are a group of phytotoxins that can induce human liver injury, particularly hepatic sinusoidal obstruction syndrome (HSOS). To date, the molecular targets of PA-induced HSOS are largely unknown. In this study, retrorsine (RTS), a known hepatotoxic PA, was used as a repr...

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Veröffentlicht in:	Chemical research in toxicology 2015-09, Vol.28 (9), p.1715-1727
Hauptverfasser:	Li, Yan-Hong, Tai, William Chi-Shing, Xue, Jun-Yi, Wong, Wing-Yan, Lu, Cheng, Ruan, Jian-Qing, Li, Na, Wan, Tai-Fung, Chan, Wood-Yee, Hsiao, Wen-Luan Wendy, Lin, Ge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cluster Analysis Hepatic Veno-Occlusive Disease - chemically induced Male Proteomics Pyrrolizidine Alkaloids - toxicity Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
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