Incidence and spectrum of paraneoplastic neurological syndromes: single center study
Paraneoplastic neurological syndromes (PNS) are remote effects of cancer. They are much less common, but are nevertheless important because they cause severe neurological morbidity and mortality. The present cases were studied to characterize the clinical features of patients of suspected PNS and to...
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| Veröffentlicht in: | Journal of neuro-oncology 2015-10, Vol.125 (1), p.197-206 |
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| creator | Kanikannan, Meena A. Sirisha, Y. Uppin, Megha S. Jabeen, Sheik A. M. Kandadai, Rukmini Sundaram, Challa Raghunadharao, Digumarti Borgohain, Rupam |
| description | Paraneoplastic neurological syndromes (PNS) are remote effects of cancer. They are much less common, but are nevertheless important because they cause severe neurological morbidity and mortality. The present cases were studied to characterize the clinical features of patients of suspected PNS and to study their association with different types of tumors. In this study conducted from a super speciality teaching institute from South India, forty five (incidence-0.25 %) patients were diagnosed with PNS based on the clinical data. They were subdivided into two groups patients with central nervous system (CNS) manifestations and those with neuromuscular manifestations. Immunological markers were assessed in a subset of patients. Majority of them (75.6 %) were above 40 years. There was no sex predilection and a chronic presentation was common (42.2 %). While more than half had involvement of peripheral nervous system (64.4 %), CNS manifestations were present in 16 (35.6 %) cases. Immunological markers were present in 10 out of 14 (58.8 %) patients. Classic PNS was seen 22 cases (48.9 %), while 23 (51.1 %) were non classical. Most common tumor was lung cancer followed by myeloma and breast carcinoma. Present study construed that, in patients with neurological syndromes of unknown cause, search should be focused for occult malignancy based on the phenotype and onconeural antibodies, targeting the lung and breast in particular. |
| doi_str_mv | 10.1007/s11060-015-1898-7 |
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Kandadai, Rukmini ; Sundaram, Challa ; Raghunadharao, Digumarti ; Borgohain, Rupam</creator><creatorcontrib>Kanikannan, Meena A. ; Sirisha, Y. ; Uppin, Megha S. ; Jabeen, Sheik A. ; M. Kandadai, Rukmini ; Sundaram, Challa ; Raghunadharao, Digumarti ; Borgohain, Rupam</creatorcontrib><description>Paraneoplastic neurological syndromes (PNS) are remote effects of cancer. They are much less common, but are nevertheless important because they cause severe neurological morbidity and mortality. The present cases were studied to characterize the clinical features of patients of suspected PNS and to study their association with different types of tumors. In this study conducted from a super speciality teaching institute from South India, forty five (incidence-0.25 %) patients were diagnosed with PNS based on the clinical data. They were subdivided into two groups patients with central nervous system (CNS) manifestations and those with neuromuscular manifestations. Immunological markers were assessed in a subset of patients. Majority of them (75.6 %) were above 40 years. There was no sex predilection and a chronic presentation was common (42.2 %). While more than half had involvement of peripheral nervous system (64.4 %), CNS manifestations were present in 16 (35.6 %) cases. Immunological markers were present in 10 out of 14 (58.8 %) patients. Classic PNS was seen 22 cases (48.9 %), while 23 (51.1 %) were non classical. Most common tumor was lung cancer followed by myeloma and breast carcinoma. Present study construed that, in patients with neurological syndromes of unknown cause, search should be focused for occult malignancy based on the phenotype and onconeural antibodies, targeting the lung and breast in particular.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-015-1898-7</identifier><identifier>PMID: 26307447</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies - metabolism ; Child ; Child, Preschool ; Clinical Study ; Female ; Humans ; Incidence ; India - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neural Conduction - physiology ; Neuroimaging ; Neurology ; Oncology ; Paraneoplastic Syndromes, Nervous System - diagnosis ; Paraneoplastic Syndromes, Nervous System - epidemiology ; Paraneoplastic Syndromes, Nervous System - immunology ; Paraneoplastic Syndromes, Nervous System - pathology ; Peripheral Nerves - pathology ; Peripheral Nerves - physiopathology ; Retrospective Studies ; Young Adult</subject><ispartof>Journal of neuro-oncology, 2015-10, Vol.125 (1), p.197-206</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-74e9aefec27b6e597fd2d8605156aab2ea17e09b3fba70eefc87be4c72627d113</citedby><cites>FETCH-LOGICAL-c475t-74e9aefec27b6e597fd2d8605156aab2ea17e09b3fba70eefc87be4c72627d113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-015-1898-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-015-1898-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26307447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanikannan, Meena A.</creatorcontrib><creatorcontrib>Sirisha, Y.</creatorcontrib><creatorcontrib>Uppin, Megha S.</creatorcontrib><creatorcontrib>Jabeen, Sheik A.</creatorcontrib><creatorcontrib>M. Kandadai, Rukmini</creatorcontrib><creatorcontrib>Sundaram, Challa</creatorcontrib><creatorcontrib>Raghunadharao, Digumarti</creatorcontrib><creatorcontrib>Borgohain, Rupam</creatorcontrib><title>Incidence and spectrum of paraneoplastic neurological syndromes: single center study</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Paraneoplastic neurological syndromes (PNS) are remote effects of cancer. They are much less common, but are nevertheless important because they cause severe neurological morbidity and mortality. The present cases were studied to characterize the clinical features of patients of suspected PNS and to study their association with different types of tumors. In this study conducted from a super speciality teaching institute from South India, forty five (incidence-0.25 %) patients were diagnosed with PNS based on the clinical data. They were subdivided into two groups patients with central nervous system (CNS) manifestations and those with neuromuscular manifestations. Immunological markers were assessed in a subset of patients. Majority of them (75.6 %) were above 40 years. There was no sex predilection and a chronic presentation was common (42.2 %). While more than half had involvement of peripheral nervous system (64.4 %), CNS manifestations were present in 16 (35.6 %) cases. Immunological markers were present in 10 out of 14 (58.8 %) patients. Classic PNS was seen 22 cases (48.9 %), while 23 (51.1 %) were non classical. Most common tumor was lung cancer followed by myeloma and breast carcinoma. Present study construed that, in patients with neurological syndromes of unknown cause, search should be focused for occult malignancy based on the phenotype and onconeural antibodies, targeting the lung and breast in particular.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Study</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neural Conduction - physiology</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Paraneoplastic Syndromes, Nervous System - diagnosis</subject><subject>Paraneoplastic Syndromes, Nervous System - epidemiology</subject><subject>Paraneoplastic Syndromes, Nervous System - immunology</subject><subject>Paraneoplastic Syndromes, Nervous System - pathology</subject><subject>Peripheral Nerves - pathology</subject><subject>Peripheral Nerves - physiopathology</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1r3DAQhkVpaTZJf0AuRdBLLk41-ho7txKaDwj0kkJuQpbHi4Mtu5J92H9fL5uGECjkNAc976uRHsbOQFyAEPg9AwgrCgGmgLIqC_zANmBQFahQfWQbARYLU-nHI3ac85MQQqOCz-xIWiVQa9ywh7sYuoZiIO5jw_NEYU7LwMeWTz75SOPU-zx3gUda0tiP2y74nuddbNI4UL7kuYvbnnigOFPieV6a3Sn71Po-05fnecJ-X_98uLot7n_d3F39uC-CRjMXqKny1FKQWFsyFbaNbEorDBjrfS3JA5KoatXWHgVRG0qsSQeUVmIDoE7Y-aF3SuOfhfLshi4H6vv93kt2gBJtBUZV70DXHwRltF7Rb2_Qp3FJcX3Inqq0tSDLlYIDFdKYc6LWTakbfNo5EG5vxx3suNWO29txuGa-Pjcv9UDNS-KfjhWQByCvR3FL6dXV_239CzgrmuE</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Kanikannan, Meena A.</creator><creator>Sirisha, Y.</creator><creator>Uppin, Megha S.</creator><creator>Jabeen, Sheik A.</creator><creator>M. 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Kandadai, Rukmini ; Sundaram, Challa ; Raghunadharao, Digumarti ; Borgohain, Rupam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-74e9aefec27b6e597fd2d8605156aab2ea17e09b3fba70eefc87be4c72627d113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Study</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neural Conduction - physiology</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Paraneoplastic Syndromes, Nervous System - diagnosis</topic><topic>Paraneoplastic Syndromes, Nervous System - epidemiology</topic><topic>Paraneoplastic Syndromes, Nervous System - immunology</topic><topic>Paraneoplastic Syndromes, Nervous System - pathology</topic><topic>Peripheral Nerves - pathology</topic><topic>Peripheral Nerves - physiopathology</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanikannan, Meena A.</creatorcontrib><creatorcontrib>Sirisha, Y.</creatorcontrib><creatorcontrib>Uppin, Megha S.</creatorcontrib><creatorcontrib>Jabeen, Sheik A.</creatorcontrib><creatorcontrib>M. Kandadai, Rukmini</creatorcontrib><creatorcontrib>Sundaram, Challa</creatorcontrib><creatorcontrib>Raghunadharao, Digumarti</creatorcontrib><creatorcontrib>Borgohain, Rupam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanikannan, Meena A.</au><au>Sirisha, Y.</au><au>Uppin, Megha S.</au><au>Jabeen, Sheik A.</au><au>M. Kandadai, Rukmini</au><au>Sundaram, Challa</au><au>Raghunadharao, Digumarti</au><au>Borgohain, Rupam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and spectrum of paraneoplastic neurological syndromes: single center study</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>125</volume><issue>1</issue><spage>197</spage><epage>206</epage><pages>197-206</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>Paraneoplastic neurological syndromes (PNS) are remote effects of cancer. They are much less common, but are nevertheless important because they cause severe neurological morbidity and mortality. The present cases were studied to characterize the clinical features of patients of suspected PNS and to study their association with different types of tumors. In this study conducted from a super speciality teaching institute from South India, forty five (incidence-0.25 %) patients were diagnosed with PNS based on the clinical data. They were subdivided into two groups patients with central nervous system (CNS) manifestations and those with neuromuscular manifestations. Immunological markers were assessed in a subset of patients. Majority of them (75.6 %) were above 40 years. There was no sex predilection and a chronic presentation was common (42.2 %). While more than half had involvement of peripheral nervous system (64.4 %), CNS manifestations were present in 16 (35.6 %) cases. Immunological markers were present in 10 out of 14 (58.8 %) patients. Classic PNS was seen 22 cases (48.9 %), while 23 (51.1 %) were non classical. Most common tumor was lung cancer followed by myeloma and breast carcinoma. Present study construed that, in patients with neurological syndromes of unknown cause, search should be focused for occult malignancy based on the phenotype and onconeural antibodies, targeting the lung and breast in particular.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26307447</pmid><doi>10.1007/s11060-015-1898-7</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Antibodies - metabolism Child Child, Preschool Clinical Study Female Humans Incidence India - epidemiology Male Medicine Medicine & Public Health Middle Aged Neural Conduction - physiology Neuroimaging Neurology Oncology Paraneoplastic Syndromes, Nervous System - diagnosis Paraneoplastic Syndromes, Nervous System - epidemiology Paraneoplastic Syndromes, Nervous System - immunology Paraneoplastic Syndromes, Nervous System - pathology Peripheral Nerves - pathology Peripheral Nerves - physiopathology Retrospective Studies Young Adult |
| title | Incidence and spectrum of paraneoplastic neurological syndromes: single center study |
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