The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population
To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients. Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2015-10, Vol.19 (10), p.561-565 |
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| container_title | Genetic testing and molecular biomarkers |
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| creator | Zhong, Xiao-Lan Miao, Hai-Jun Fang, Zhi-Min Kuken, Bannu Song, Hong-Yan Zhong, Hua Lu, Yun Liu, Shun-Min |
| description | To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients.
Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed.
After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure.
The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension. |
| doi_str_mv | 10.1089/gtmb.2015.0111 |
| format | Article |
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Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed.
After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure.
The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2015.0111</identifier><identifier>PMID: 26284905</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Asian Continental Ancestry Group ; Blood Pressure Monitoring, Ambulatory ; Case-Control Studies ; China ; Female ; Gene Frequency ; Genetic Association Studies ; Humans ; Hypertension - blood ; Hypertension - genetics ; Hypertension - physiopathology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Sirtuin 1 - genetics</subject><ispartof>Genetic testing and molecular biomarkers, 2015-10, Vol.19 (10), p.561-565</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-32d4a195373c43d6a6ed2a084dc4129e7a9edcb2b89a5e7d44d7e4352abc450c3</citedby><cites>FETCH-LOGICAL-c328t-32d4a195373c43d6a6ed2a084dc4129e7a9edcb2b89a5e7d44d7e4352abc450c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26284905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, Xiao-Lan</creatorcontrib><creatorcontrib>Miao, Hai-Jun</creatorcontrib><creatorcontrib>Fang, Zhi-Min</creatorcontrib><creatorcontrib>Kuken, Bannu</creatorcontrib><creatorcontrib>Song, Hong-Yan</creatorcontrib><creatorcontrib>Zhong, Hua</creatorcontrib><creatorcontrib>Lu, Yun</creatorcontrib><creatorcontrib>Liu, Shun-Min</creatorcontrib><title>The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients.
Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed.
After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure.
The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension.</description><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sirtuin 1 - genetics</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkTtPwzAURi0EoqWwMiKPLC1-5jGiikdFJSQoc-TYN20giYPtIIVfT0NLZybf4Xxn8EHokpIZJUl6sw51PmOEyhmhlB6hMU2FnBIm4-PDHckROvP-nZBI8CQ6RSMWsUSkRI5Rt9oAhqIAHbAt8OviZUXxGhrAra362rp2U_raY9tgVeddpYJ1Pc4raw1uHXjfORiGm74FF6Dx5dd2qkIJTfC4bHDY-p_Ut_rYbI3tIChtc45OClV5uNi_E_R2f7eaP06Xzw-L-e1yqjlLwpQzIxRNJY-5FtxEKgLDFEmE0YKyFGKVgtE5y5NUSYiNECYGwSVTuRaSaD5B1ztv6-xnBz5kdek1VJVqwHY-ozGLo5QO__IPlAgR0190tkO1s947KLLWlbVyfUZJNlTJhirZUCUbqmwHV3t3l9dgDvhfBv4DV3WKKg</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Zhong, Xiao-Lan</creator><creator>Miao, Hai-Jun</creator><creator>Fang, Zhi-Min</creator><creator>Kuken, Bannu</creator><creator>Song, Hong-Yan</creator><creator>Zhong, Hua</creator><creator>Lu, Yun</creator><creator>Liu, Shun-Min</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201510</creationdate><title>The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population</title><author>Zhong, Xiao-Lan ; Miao, Hai-Jun ; Fang, Zhi-Min ; Kuken, Bannu ; Song, Hong-Yan ; Zhong, Hua ; Lu, Yun ; Liu, Shun-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-32d4a195373c43d6a6ed2a084dc4129e7a9edcb2b89a5e7d44d7e4352abc450c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sirtuin 1 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Xiao-Lan</creatorcontrib><creatorcontrib>Miao, Hai-Jun</creatorcontrib><creatorcontrib>Fang, Zhi-Min</creatorcontrib><creatorcontrib>Kuken, Bannu</creatorcontrib><creatorcontrib>Song, Hong-Yan</creatorcontrib><creatorcontrib>Zhong, Hua</creatorcontrib><creatorcontrib>Lu, Yun</creatorcontrib><creatorcontrib>Liu, Shun-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Xiao-Lan</au><au>Miao, Hai-Jun</au><au>Fang, Zhi-Min</au><au>Kuken, Bannu</au><au>Song, Hong-Yan</au><au>Zhong, Hua</au><au>Lu, Yun</au><au>Liu, Shun-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2015-10</date><risdate>2015</risdate><volume>19</volume><issue>10</issue><spage>561</spage><epage>565</epage><pages>561-565</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients.
Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed.
After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure.
The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension.</abstract><cop>United States</cop><pmid>26284905</pmid><doi>10.1089/gtmb.2015.0111</doi><tpages>5</tpages></addata></record> |
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| ispartof | Genetic testing and molecular biomarkers, 2015-10, Vol.19 (10), p.561-565 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Asian Continental Ancestry Group Blood Pressure Monitoring, Ambulatory Case-Control Studies China Female Gene Frequency Genetic Association Studies Humans Hypertension - blood Hypertension - genetics Hypertension - physiopathology Male Middle Aged Polymorphism, Single Nucleotide Sirtuin 1 - genetics |
| title | The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population |
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