The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway: e1005503

Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic Parkinson's disease (PD). We have identified two novel LRRK2-associated proteins, a HECT-type ubiquitin ligase, HERC2, and an adaptor-like protein with six repeated Neuralized domains, NEURL4....

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Veröffentlicht in:	PLoS genetics 2015-09, Vol.11 (9)
Hauptverfasser:	Imai, Yuzuru, Kobayashi, Yoshito, Inoshita, Tsuyoshi, Meng, Hongrui, Arano, Taku, Uemura, Kengo, Asano, Takeshi, Yoshimi, Kenji, Zhang, Chang-Liang, Matsumoto, Gen, Ohtsuka, Toshiyuki, Kageyama, Ryoichiro, Kiyonari, Hiroshi, Shioi, Go, Nukina, Nobuyuki, Hattori, Nobutaka, Takahashi, Ryosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Genes Kinases Mutation Parkinson's disease
Online-Zugang:	Volltext
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