Polar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13L: e0137787

The Kunitz-type protease inhibitor ShPI-1 inhibits human neutrophil elastase (HNE, Ki = 2.35.10-8 M) but does not interact with the porcine pancreatic elastase (PPE); whereas its P1 site variant, ShPI-1/K13L, inhibits both HNE and PPE (Ki = 1.3.10-9 M, and Ki = 1.2.10-8 M, respectively). By employin...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9)
Hauptverfasser:	Gonzalez, Jorge EnriqueHernandez, Garcia-Fernandez, Rossana, Valiente, Pedro Alberto
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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