The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival
Epithelium-specific Ets transcription factor 1 ( ESE-1 ) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that ESE-1 is constitutivel...
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| Veröffentlicht in: | Genes and immunity 2015-07, Vol.16 (5), p.356-361 |
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| creator | Lee, C M Gupta, S Parodo, J Wu, J Marshall, J C Hu, J |
| description | Epithelium-specific Ets transcription factor 1 (
ESE-1
) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that
ESE-1
is constitutively expressed in human, but not in murine, neutrophils and that
ESE-1
is modestly upregulated in septic patient neutrophils. In normal human neutrophils,
ESE-1
was detected at both RNA and protein levels but was found to be an unstable nuclear protein
ex vivo. ESE-1
transcription was also induced during all-
trans
retinoic acid-mediated HL-60 differentiation, a human promyelocytic cell line often used as an
in vitro
model of human neutrophils.
Elf3−/−
mice had normal neutrophils but a reduced number of circulating B-lymphocytes. These findings indicate a potential role of
ESE-1
in regulating human neutrophil differentiation and function, and that it has different roles in the immune system of different species. |
| doi_str_mv | 10.1038/gene.2015.10 |
| format | Article |
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ESE-1
) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that
ESE-1
is constitutively expressed in human, but not in murine, neutrophils and that
ESE-1
is modestly upregulated in septic patient neutrophils. In normal human neutrophils,
ESE-1
was detected at both RNA and protein levels but was found to be an unstable nuclear protein
ex vivo. ESE-1
transcription was also induced during all-
trans
retinoic acid-mediated HL-60 differentiation, a human promyelocytic cell line often used as an
in vitro
model of human neutrophils.
Elf3−/−
mice had normal neutrophils but a reduced number of circulating B-lymphocytes. These findings indicate a potential role of
ESE-1
in regulating human neutrophil differentiation and function, and that it has different roles in the immune system of different species.</description><identifier>ISSN: 1466-4879</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/gene.2015.10</identifier><identifier>PMID: 25906252</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/31 ; 13/44 ; 38/77 ; 38/90 ; 631/250/2504/223/1699 ; 64/110 ; 82/1 ; 82/80 ; 96/106 ; Animals ; B-Lymphocytes - cytology ; B-Lymphocytes - drug effects ; B-Lymphocytes - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell differentiation ; Cell Line ; Cellular control mechanisms ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Epithelial cells ; Epithelium ; ETS protein ; Gene Expression ; Genetic aspects ; Health aspects ; Human Genetics ; Humans ; Immune response ; Immune system ; Immunology ; Inflammation ; Leukocytes (neutrophilic) ; Leukopoiesis ; Lymphocytes B ; Mice ; Neutrophils ; Neutrophils - cytology ; Neutrophils - drug effects ; Neutrophils - metabolism ; Physiological aspects ; Properties ; Proto-Oncogene Proteins c-ets - genetics ; Proto-Oncogene Proteins c-ets - metabolism ; Retinoic acid ; Ribonucleic acid ; RNA ; short-communication ; Species Specificity ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Tretinoin - pharmacology</subject><ispartof>Genes and immunity, 2015-07, Vol.16 (5), p.356-361</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c661t-a2184d1bf259122f699d85381d3482552d09bba76e196bb3d614bc4438b9e7913</citedby><cites>FETCH-LOGICAL-c661t-a2184d1bf259122f699d85381d3482552d09bba76e196bb3d614bc4438b9e7913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/gene.2015.10$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/gene.2015.10$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25906252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, C M</creatorcontrib><creatorcontrib>Gupta, S</creatorcontrib><creatorcontrib>Parodo, J</creatorcontrib><creatorcontrib>Wu, J</creatorcontrib><creatorcontrib>Marshall, J C</creatorcontrib><creatorcontrib>Hu, J</creatorcontrib><title>The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><addtitle>Genes Immun</addtitle><description>Epithelium-specific Ets transcription factor 1 (
ESE-1
) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that
ESE-1
is constitutively expressed in human, but not in murine, neutrophils and that
ESE-1
is modestly upregulated in septic patient neutrophils. In normal human neutrophils,
ESE-1
was detected at both RNA and protein levels but was found to be an unstable nuclear protein
ex vivo. ESE-1
transcription was also induced during all-
trans
retinoic acid-mediated HL-60 differentiation, a human promyelocytic cell line often used as an
in vitro
model of human neutrophils.
Elf3−/−
mice had normal neutrophils but a reduced number of circulating B-lymphocytes. These findings indicate a potential role of
ESE-1
in regulating human neutrophil differentiation and function, and that it has different roles in the immune system of different species.</description><subject>13/31</subject><subject>13/44</subject><subject>38/77</subject><subject>38/90</subject><subject>631/250/2504/223/1699</subject><subject>64/110</subject><subject>82/1</subject><subject>82/80</subject><subject>96/106</subject><subject>Animals</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell differentiation</subject><subject>Cell Line</subject><subject>Cellular control mechanisms</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>ETS protein</subject><subject>Gene Expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Leukopoiesis</subject><subject>Lymphocytes B</subject><subject>Mice</subject><subject>Neutrophils</subject><subject>Neutrophils - cytology</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Physiological aspects</subject><subject>Properties</subject><subject>Proto-Oncogene Proteins c-ets - genetics</subject><subject>Proto-Oncogene Proteins c-ets - metabolism</subject><subject>Retinoic acid</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>short-communication</subject><subject>Species Specificity</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Tretinoin - pharmacology</subject><issn>1466-4879</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0s1rFDEYB-Agiq2rN88S8GLBWfP94W0pqxYKgq3nkJnJ7KbMJGsys-h_34xbbStFZQ4z7_DkTfLyA-AlRkuMqHq3ccEtCcK8lI_AMWZSVJxJ9Hj-FqJiSuoj8CznK4SwwEI_BUeEayQIJ8fAX24dnEIT9y75sIGxg-uLdYWhD3A7DTbA4KYxxd3W9_k99MOu940dfQwz9WOGKfZu1rcOdqXhT2JDC_OU9n5v--fgSWf77F7cvBfg64f15emn6vzzx7PT1XnVCIHHyhKsWIvrrpwRE9IJrVvFqcItZYpwTlqk69pK4bAWdU1bgVndMEZVrZ3UmC7Am0PfXYrfJpdHM_jcuL63wcUpGyyJFEoIrv9NhVZacM5poa__oFdxSqFcxBBKy1yloH9VBTClCMHyVm1s74wPXRyTbeatzYoRhhGXSBS1fECVp3WDb2JwnS__7y04ubegmNF9Hzd2ytmcXXwxK4ERQbzc_T_s3b5vD7ZJMefkOrNLfrDph8HIzBE0cwTNHMG5XIBXNzOY6sG1v_GvzBVQHUDezZFz6c6QHmp4DXPx4As</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Lee, C M</creator><creator>Gupta, S</creator><creator>Parodo, J</creator><creator>Wu, J</creator><creator>Marshall, J C</creator><creator>Hu, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival</title><author>Lee, C M ; Gupta, S ; Parodo, J ; Wu, J ; Marshall, J C ; Hu, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c661t-a2184d1bf259122f699d85381d3482552d09bba76e196bb3d614bc4438b9e7913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13/31</topic><topic>13/44</topic><topic>38/77</topic><topic>38/90</topic><topic>631/250/2504/223/1699</topic><topic>64/110</topic><topic>82/1</topic><topic>82/80</topic><topic>96/106</topic><topic>Animals</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell differentiation</topic><topic>Cell Line</topic><topic>Cellular control mechanisms</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Epithelial cells</topic><topic>Epithelium</topic><topic>ETS protein</topic><topic>Gene Expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Leukocytes (neutrophilic)</topic><topic>Leukopoiesis</topic><topic>Lymphocytes B</topic><topic>Mice</topic><topic>Neutrophils</topic><topic>Neutrophils - cytology</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Physiological aspects</topic><topic>Properties</topic><topic>Proto-Oncogene Proteins c-ets - 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Academic</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, C M</au><au>Gupta, S</au><au>Parodo, J</au><au>Wu, J</au><au>Marshall, J C</au><au>Hu, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival</atitle><jtitle>Genes and immunity</jtitle><stitle>Genes Immun</stitle><addtitle>Genes Immun</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>16</volume><issue>5</issue><spage>356</spage><epage>361</epage><pages>356-361</pages><issn>1466-4879</issn><eissn>1476-5470</eissn><abstract>Epithelium-specific Ets transcription factor 1 (
ESE-1
) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that
ESE-1
is constitutively expressed in human, but not in murine, neutrophils and that
ESE-1
is modestly upregulated in septic patient neutrophils. In normal human neutrophils,
ESE-1
was detected at both RNA and protein levels but was found to be an unstable nuclear protein
ex vivo. ESE-1
transcription was also induced during all-
trans
retinoic acid-mediated HL-60 differentiation, a human promyelocytic cell line often used as an
in vitro
model of human neutrophils.
Elf3−/−
mice had normal neutrophils but a reduced number of circulating B-lymphocytes. These findings indicate a potential role of
ESE-1
in regulating human neutrophil differentiation and function, and that it has different roles in the immune system of different species.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25906252</pmid><doi>10.1038/gene.2015.10</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genes and immunity, 2015-07, Vol.16 (5), p.356-361 |
| issn | 1466-4879 1476-5470 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | 13/31 13/44 38/77 38/90 631/250/2504/223/1699 64/110 82/1 82/80 96/106 Animals B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Cell differentiation Cell Line Cellular control mechanisms DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epithelial cells Epithelium ETS protein Gene Expression Genetic aspects Health aspects Human Genetics Humans Immune response Immune system Immunology Inflammation Leukocytes (neutrophilic) Leukopoiesis Lymphocytes B Mice Neutrophils Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Physiological aspects Properties Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Retinoic acid Ribonucleic acid RNA short-communication Species Specificity Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Tretinoin - pharmacology |
| title | The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival |
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