Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons

Highlights • We provided the first evidence that maxadilan and BAY 55-9837 cause Ca2+ -influx in TRG neurons. • The TRG culture is an appropriate model to study PACAP signaling. • PACAP6-38, M65 and VIP6-28 have agonistic action on TRG neurons. • The VPAC1 receptor does not play a role in the PACAP...

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Veröffentlicht in:	Neuroscience 2015-11, Vol.308, p.144-156
Hauptverfasser:	Sághy, É, Payrits, M, Helyes, Zs, Reglődi, D, Bánki, E, Tóth, G, Couvineau, A, Szőke, É
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cells, Cultured CHO Cells Cricetulus G protein-coupled receptor Humans Insect Proteins - pharmacology Mice Neurology PAC1 PACAP6-38 Peptide Fragments - pharmacology Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology Rats, Wistar Receptors, Vasoactive Intestinal Peptide, Type II - antagonists & inhibitors Receptors, Vasoactive Intestinal Peptide, Type II - metabolism Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Sensory System Agents - pharmacology trigeminal ganglia Trigeminal Ganglion - drug effects Trigeminal Ganglion - physiology TRPV Cation Channels - metabolism Vasoactive Intestinal Peptide - pharmacology Voltage-Sensitive Dye Imaging VPAC1 VPAC2
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Zusammenfassung:	Highlights • We provided the first evidence that maxadilan and BAY 55-9837 cause Ca2+ -influx in TRG neurons. • The TRG culture is an appropriate model to study PACAP signaling. • PACAP6-38, M65 and VIP6-28 have agonistic action on TRG neurons. • The VPAC1 receptor does not play a role in the PACAP signaling TRG neurons. • The receptor involved in PACAP-induced TRG activation needs to be identified.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.043