The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats

•We examined the role of a selective kappa-receptor antagonist on opioid withdrawal.•Nor-BNI 5h prior to withdrawal reduced feces excreted in morphine-dependent rats.•Nor-BNI 5h prior to withdrawal reduced the conditioned place aversion 2 days later.•Nor-BNI 2h following withdrawal did not affect th...

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Veröffentlicht in:	Behavioural brain research 2015-04, Vol.283, p.16-21
Hauptverfasser:	Kelsey, John E., Verhaak, Allison M.S., Schierberl, Kathryn C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Conditioned place aversion Conditioning (Psychology) - drug effects Defecation - drug effects Dynorphin Dynorphins - pharmacology Kappa receptors Male Morphine Morphine - administration & dosage Morphine Dependence - drug therapy Morphine Dependence - physiopathology Motor Activity - drug effects Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology Narcotics - administration & dosage Neurotransmitter Agents - pharmacology Nor-BNI Random Allocation Rats, Long-Evans Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - metabolism Spatial Behavior - drug effects Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - physiopathology Withdrawal
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