Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay

•Presents follow-up strategy for in vitro micronucleus positive test results.•Uses histone markers to discriminate aneugens, clastogens and cytotoxicants.•Improves specificity of TK6 in vitro mincronucleus assay.•Identifies novel biomarker for clastogenic compounds. The in vitro micronucleus assay w...

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Veröffentlicht in:	Mutation research. Genetic toxicology and environmental mutagenesis 2015-01, Vol.777, p.7-16
Hauptverfasser:	Cheung, Jennifer R., Dickinson, Donna A., Moss, Jocelyn, Schuler, Maik J., Spellman, Richard A., Heard, Pamela L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneugenicity Aneugens - pharmacology Apoptosis - drug effects Bioassays Biomarkers - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cell Cycle - drug effects Cell Line, Tumor Clastogenicity Etoposide - pharmacology Flow Cytometry Gene Expression - drug effects H2AX Histones - genetics Histones - metabolism Humans In vitro micronucleus assay Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Micronucleus Tests Mutagens - pharmacology Noscapine - pharmacology Phosphorylation Polyploidy Proteins TK6 Toxicity Tunicamycin - pharmacology
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