Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts

Nevirapine (NVP) is the non-nucleoside HIV-1 reverse transcriptase inhibitor most commonly used in developing countries, both as a component of combined antiretroviral therapy and to prevent mother-to-child transmission of the virus; however, severe hepatotoxicity and serious adverse cutaneous effec...

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Veröffentlicht in:	Toxicology research (Cambridge) 2015-01, Vol.4 (6), p.1565-1577
Hauptverfasser:	Harjivan, Shrika G., Pinheiro, Pedro F., Martins, Inês L., Godinho, Ana L., Wanke, Riccardo, Santos, Pedro P., Pereira, Sofia A., Beland, Frederick A., Marques, M. Matilde, Antunes, Alexandra M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Human immunodeficiency virus 1
Online-Zugang:	Volltext
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