Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage

The intestinal epithelial barrier plays a critical role in the mucosal immunity. However, it remains largely unknown how the epithelial barrier is maintained after damage. Here we show that growth factor FGF2 synergized with interleukin-17 (IL-17) to induce genes for repairing of damaged epithelium....

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-09, Vol.43 (3), p.488-501
Hauptverfasser:	Song, Xinyang, Dai, Dai, He, Xiao, Zhu, Shu, Yao, Yikun, Gao, Hanchao, Wang, Jingjing, Qu, Fangfang, Qiu, Ju, Wang, Honglin, Li, Xiaoxia, Shen, Nan, Qian, Youcun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Adenoviruses Animals Apoptosis Blotting, Western Cell growth Cell Line, Tumor Cells, Cultured Colitis - genetics Colitis - immunology Colitis - metabolism Colon Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - immunology Fibroblast Growth Factor 2 - metabolism Gene expression Gene Expression Profiling - methods Growth factors HEK293 Cells HeLa Cells Homeostasis HT29 Cells Humans Immune system Inflammatory bowel disease Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intestines - immunology Intestines - microbiology Intestines - pathology Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microbiota - genetics Microbiota - immunology Oligonucleotide Array Sequence Analysis Pathogenesis Reverse Transcriptase Polymerase Chain Reaction Rodents T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - immunology Transforming Growth Factor beta - metabolism Wound Healing - immunology
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