Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture
Progressive increase in membrane resting potential (MRP) values in cultured chick embryo brain neurons were recorded from days 2 to 10 of development. Application of corticosterone or prednisone in 24 hr old cultured cells caused a significant increment in MRP recorded at day 2 of culture with respe...
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| Veröffentlicht in: | International journal of developmental neuroscience 1985, Vol.3 (5), p.521-523 |
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| container_title | International journal of developmental neuroscience |
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| creator | Romano, Marta C. Velázquez, P.N. Nún̄ez, M. Bonilla Fuentes‐Pardo, Beatriz |
| description | Progressive increase in membrane resting potential (MRP) values in cultured chick embryo brain neurons were recorded from days 2 to 10 of development. Application of corticosterone or prednisone in 24 hr old cultured cells caused a significant increment in MRP recorded at day 2 of culture with respect to control. When ouabain was added to the corticosterone treated cells its effect on the MRP was impaired. An increment in protein synthesis and a reduction in sodium concentration were also observed in corticosterone pretreated cells. These results show that corticoids accelerate the differentiation process in cultured cells particularly the MRP, stimulating perhaps the Na+‐K+ ATPase pump. |
| doi_str_mv | 10.1016/0736-5748(85)90041-3 |
| format | Article |
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These results show that corticoids accelerate the differentiation process in cultured cells particularly the MRP, stimulating perhaps the Na+‐K+ ATPase pump.</description><identifier>ISSN: 0736-5748</identifier><identifier>EISSN: 1873-474X</identifier><identifier>DOI: 10.1016/0736-5748(85)90041-3</identifier><identifier>PMID: 24874961</identifier><identifier>CODEN: IJDND6</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Biological and medical sciences ; brain ; Chick embryo brain ; chickens ; Corticoids ; Development ; Embryology: invertebrates and vertebrates. Teratology ; embryos ; Experimental organogenesis ; Fundamental and applied biological sciences. Psychology ; glucocorticoids ; membrane potential ; Membrane resting potential ; Organogenesis. 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Bonilla</creatorcontrib><creatorcontrib>Fuentes‐Pardo, Beatriz</creatorcontrib><title>Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture</title><title>International journal of developmental neuroscience</title><addtitle>Int J Dev Neurosci</addtitle><description>Progressive increase in membrane resting potential (MRP) values in cultured chick embryo brain neurons were recorded from days 2 to 10 of development. Application of corticosterone or prednisone in 24 hr old cultured cells caused a significant increment in MRP recorded at day 2 of culture with respect to control. When ouabain was added to the corticosterone treated cells its effect on the MRP was impaired. An increment in protein synthesis and a reduction in sodium concentration were also observed in corticosterone pretreated cells. These results show that corticoids accelerate the differentiation process in cultured cells particularly the MRP, stimulating perhaps the Na+‐K+ ATPase pump.</description><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Chick embryo brain</subject><subject>chickens</subject><subject>Corticoids</subject><subject>Development</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>embryos</subject><subject>Experimental organogenesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glucocorticoids</subject><subject>membrane potential</subject><subject>Membrane resting potential</subject><subject>Organogenesis. 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Physiological fonctions</topic><topic>Ouabain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romano, Marta C.</creatorcontrib><creatorcontrib>Velázquez, P.N.</creatorcontrib><creatorcontrib>Nún̄ez, M. 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| identifier | ISSN: 0736-5748 |
| ispartof | International journal of developmental neuroscience, 1985, Vol.3 (5), p.521-523 |
| issn | 0736-5748 1873-474X |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences brain Chick embryo brain chickens Corticoids Development Embryology: invertebrates and vertebrates. Teratology embryos Experimental organogenesis Fundamental and applied biological sciences. Psychology glucocorticoids membrane potential Membrane resting potential Organogenesis. Physiological fonctions Ouabain |
| title | Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture |
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