Neonatal Withdrawal Following Pre- and Postnatal Exposure to Methadone in the Rat

Recent evidence has shown that infant rats undergo precipitated withdrawal following chronic postnatal injection of morphine. In this study we examined whether or not infants exposed to methadone prenatally via the placental blood supply and postnatally via the dam’s milk would also experience preci...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-05, Vol.60 (1), p.97-104
Hauptverfasser:	Barr, Gordon A, Zmitrovich, Ann, Hamowy, Alexander S, Liu, Pic Yan R, Wang, Shaoning, Hutchings, Donald E
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstinence Animals Animals, Newborn Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Development Drug toxicity and drugs side effects treatment Female Humans Infant, Newborn Locomotor activity Male Medical sciences Methadone Methadone - administration & dosage Methadone - toxicity Miscellaneous (drug allergy, mutagens, teratogens...) Motor Activity - drug effects Naltrexone - pharmacology Narcotic Antagonists - pharmacology Neonatal Abstinence Syndrome - etiology Neonatal Abstinence Syndrome - psychology Opiates Osmotic minipumps Pharmacology. Drug treatments Pregnancy Rats Rats, Wistar Substance Withdrawal Syndrome - etiology Substance Withdrawal Syndrome - psychology Ultrasonic vocalizations Vocalization, Animal - drug effects Withdrawal
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