Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development

The epidermal growth factor (EGF) system has been thought to play an important role in normal mammary development and carcinogenesis. To study the role of the EGF receptor (EGFR) in mammary development, we developed a transgenic mouse model in which a C-terminal truncated mouse EGFR (EGFR-TR) was ex...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 1997-11, Vol.11 (12), p.1766-1781
Hauptverfasser:	Xie, W, Paterson, A J, Chin, E, Nabell, L M, Kudlow, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Animals DNA - biosynthesis DNA - genetics Epithelial Cells - metabolism Female Gene Expression Regulation, Developmental Gene Targeting Genes, Dominant Mammary Glands, Animal - growth & development Mammary Glands, Animal - pathology Mammary Tumor Virus, Mouse - genetics Mice Mice, Inbred C57BL Mice, Transgenic Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - physiology Transgenes
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