Regenerative medicine in otorhinolaryngology
Tissue engineering using biocompatible scaffolds, with or without cells, can permit surgeons to restore structure and function following tissue resection or in cases of congenital abnormality. Tracheal regeneration has emerged as a spearhead application of these technologies, whilst regenerative the...
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| Veröffentlicht in: | Journal of laryngology and otology 2015-08, Vol.129 (8), p.732-739 |
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| container_title | Journal of laryngology and otology |
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| creator | Wormald, J C R Fishman, J M Juniat, S Tolley, N Birchall, M A |
| description | Tissue engineering using biocompatible scaffolds, with or without cells, can permit surgeons to restore structure and function following tissue resection or in cases of congenital abnormality. Tracheal regeneration has emerged as a spearhead application of these technologies, whilst regenerative therapies are now being developed to treat most other diseases within otolaryngology.
A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed.
The main issues facing research in regenerative surgery are translation of animal model work into human models, increasing stem cell availability so it can be used to further research, and development of better facilities to enable implementation of these advances. |
| doi_str_mv | 10.1017/S0022215115001577 |
| format | Article |
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A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed.
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A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed.
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Fishman, J M ; Juniat, S ; Tolley, N ; Birchall, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-8a4f59b9c18899ea3fc21b50fae74e00d28e31a0cd3457a54cfd5ca6bc44d42c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biocompatible Materials</topic><topic>Boolean</topic><topic>Clinical trials</topic><topic>Cognition & reasoning</topic><topic>Disease</topic><topic>Forecasting</topic><topic>Hair</topic><topic>Hearing loss</topic><topic>Hearing protection</topic><topic>Humans</topic><topic>Otolaryngology</topic><topic>Otolaryngology - methods</topic><topic>Otolaryngology - trends</topic><topic>Otology</topic><topic>Otorhinolaryngologic Diseases - surgery</topic><topic>Regenerative medicine</topic><topic>Regenerative Medicine - methods</topic><topic>Regenerative Medicine - trends</topic><topic>Review Articles</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem Cell Transplantation - trends</topic><topic>Stem cells</topic><topic>Surgery</topic><topic>Tissue engineering</topic><topic>Tissue Scaffolds</topic><topic>Trachea - surgery</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wormald, J C R</creatorcontrib><creatorcontrib>Fishman, J M</creatorcontrib><creatorcontrib>Juniat, S</creatorcontrib><creatorcontrib>Tolley, N</creatorcontrib><creatorcontrib>Birchall, M A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wormald, J C R</au><au>Fishman, J M</au><au>Juniat, S</au><au>Tolley, N</au><au>Birchall, M A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regenerative medicine in otorhinolaryngology</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. 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| subjects | Biocompatible Materials Boolean Clinical trials Cognition & reasoning Disease Forecasting Hair Hearing loss Hearing protection Humans Otolaryngology Otolaryngology - methods Otolaryngology - trends Otology Otorhinolaryngologic Diseases - surgery Regenerative medicine Regenerative Medicine - methods Regenerative Medicine - trends Review Articles Stem Cell Transplantation - methods Stem Cell Transplantation - trends Stem cells Surgery Tissue engineering Tissue Scaffolds Trachea - surgery Transplants & implants |
| title | Regenerative medicine in otorhinolaryngology |
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