Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report
Herein, we report a case of a 20-year-old (ethnicity not reported) woman with a history of nitrous oxide abuse and clinical symptoms consistent with spinal cord subacute combined degeneration with associated low serum concentrations of vitamin B12, elevated methylmalonic acid levels, and radiologic...
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| Veröffentlicht in: | Laboratory medicine 2015-11, Vol.46 (4), p.312-315 |
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| creator | Duque, Miriam Andrea Kresak, Jesse L. Falchook, Adam Harris, Neil S. |
| description | Herein, we report a case of a 20-year-old (ethnicity not reported) woman with a history of nitrous oxide abuse and clinical symptoms consistent with spinal cord subacute combined degeneration with associated low serum concentrations of vitamin B12, elevated methylmalonic acid levels, and radiologic evidence of demyelination of the dorsal region of the spinal column. The health of the patient improved dramatically with B12 supplementation. In this case, we discuss the interaction of nitrous oxide with the enzymatic pathways involved in the biochemistry of vitamin B12 |
| doi_str_mv | 10.1309/LM0L9HAVXCHF1UQM |
| format | Article |
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| ispartof | Laboratory medicine, 2015-11, Vol.46 (4), p.312-315 |
| issn | 0007-5027 1943-7730 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Demyelinating Diseases Female Humans Methylmalonic Acid - blood Nitrous Oxide - adverse effects Paresthesia Spinal Cord Diseases - drug therapy Spinal Cord Diseases - etiology Spinal Cord Diseases - physiopathology Substance-Related Disorders - complications Substance-Related Disorders - diagnosis Vitamin B 12 - administration & dosage Vitamin B 12 - therapeutic use Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - complications Vitamin B 12 Deficiency - diagnosis Young Adult |
| title | Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report |
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