Evidence that the Human Cytomegalovirus 46-kDa UL72 protein is not an active dUTPase but a late protein dispensable for replication in fibroblasts

The Human Cytomegalovirus (HCMV) UL72 gene is considered to be the equivalent of the dUTPase gene of the Alpha- and Gamma-herpesviruses. To characterize its function, the expression profiles of UL72 at both the RNA and the protein level were determined. The gene is expressed with a late kinetics and...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2004-08, Vol.325 (2), p.264-276
Hauptverfasser:	Caposio, Patrizia, Riera, Ludovica, Hahn, Gabriele, Landolfo, Santo, Gribaudo, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Cells, Cultured Cytomegalovirus - genetics Cytomegalovirus - isolation & purification Cytomegalovirus - physiology Deletion mutant viruses DNA Primers - genetics DNA, Viral - genetics dUTPase Fibroblasts - virology Gene Expression Genes, Viral Herpesvirus Human cytomegalovirus Humans Molecular Sequence Data Molecular Weight Mutagenesis, Site-Directed Pyrophosphatases - chemistry Pyrophosphatases - genetics Pyrophosphatases - physiology Sequence Homology, Amino Acid UL72 gene Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - physiology Virus Replication
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