Comparison of the toxicity of fluconazole and other azole antifungal drugs to murine and human granulocyte-macrophage progenitor cells in vitro

We studied the inhibitory effects on colony formation by granulocyte-macrophage colony forming units (cfu-gm) of eight azole antifungal agents in vitro. All agents, except fluconazole, inhibited colony formation dose-dependently with 50% inhibitory concentrations (IC50) in the range of 0.78-49 micro...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1999-05, Vol.43 (5), p.675-681
Hauptverfasser:	BENKÖ, I, HERNADI, F, MEGYERI, A, KISS, A, SOMOGYI, G, TEGYEY, Z, KRAICSOVITS, F, KOVACS, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - toxicity Azoles - pharmacology Biological and medical sciences Bone Marrow - drug effects Cells, Cultured - drug effects Clotrimazole - toxicity Dose-Response Relationship, Drug Econazole - toxicity Female Fluconazole - toxicity Granulocytes - drug effects Hematopoietic Stem Cells - drug effects Humans Imidazoles - toxicity Inhibitory Concentration 50 Ketoconazole - toxicity Macrophages - drug effects Male Medical sciences Mice Miconazole - toxicity Pharmacology. Drug treatments Species Specificity Stem Cells - drug effects
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