An intranasal challenge model for testing Japanese encephalitis vaccines in rhesus monkeys

Placebo-controlled field efficacy trials of new Japanese encephalitis (JE) vaccines may be impractical. Therefore, an animal model to evaluate efficacy of candidate JE vaccines is sought. Previous work has shown that exposure of monkeys to JE virus (JEV) via the intranasal route results in encephali...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 1999-03, Vol.60 (3), p.329-337
Hauptverfasser:	Raengsakulrach, B, Nisalak, A, Gettayacamin, M, Thirawuth, V, Young, GD, Myint, KS, Ferguson, LM, Hoke CH, , Jr, Innis, BL, Vaughn, DW
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Animals, Suckling Antibodies, Viral - blood Antibodies, Viral - cerebrospinal fluid Arboviral encephalitis Arboviroses Biological and medical sciences Disease Models, Animal DNA Primers - chemistry DNA, Viral - chemistry Electrophoresis, Agar Gel Encephalitis Virus, Japanese - immunology Encephalitis Virus, Japanese - pathogenicity Encephalitis, Japanese - immunology Encephalitis, Japanese - prevention & control Enzyme-Linked Immunosorbent Assay Female Hemagglutination Inhibition Tests Human viral diseases Immunization Infectious diseases Japanese encephalitis virus Macaca mulatta Macaca rhesus Male Medical sciences Mice Neutralization Tests Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - analysis RNA, Viral - blood RNA, Viral - cerebrospinal fluid Tropical medicine Tropical viral diseases Viral diseases Viral Vaccines - administration & dosage Viral Vaccines - immunology Viral Vaccines - standards Viremia - cerebrospinal fluid
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