CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone–proguanil against falciparum malaria in Vietnam

Summary Objectives To study a new combination, based on dihydroartemisinin and piperaquine (CV8) and atovaquone/proguanil (Malarone) for treatment of uncomplicated falciparum malaria in Vietnam. Methods Vietnamese adults with falciparum malaria were allocated randomly to treatment with dihydroarte...

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Veröffentlicht in:	Tropical medicine & international health 2004-02, Vol.9 (2), p.209-216
Hauptverfasser:	Giao, Phan T., Vries, Peter J., Hung, Le Q., Binh, Tran Q., Nam, Nguyen V., Kager, Piet A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Antimalarials - administration & dosage Antimalarials - adverse effects Artemisinins - administration & dosage Artemisinins - adverse effects Atovaquone Biological and medical sciences combination therapy dihydroartemisinin Drug Combinations Drug Therapy, Combination Female Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - blood Malaria, Falciparum - drug therapy Male Medical sciences Middle Aged Naphthoquinones - adverse effects Naphthoquinones - therapeutic use Parasitemia - drug therapy Parasitic diseases piperaquine Plasmodium falciparum Plasmodium falciparum - drug effects primaquine Primaquine - administration & dosage Primaquine - adverse effects proguanil Proguanil - adverse effects Proguanil - therapeutic use Protozoal diseases Quinolines - administration & dosage Quinolines - adverse effects Sesquiterpenes - administration & dosage Sesquiterpenes - adverse effects Treatment Outcome trimethoprim Trimethoprim - administration & dosage Trimethoprim - adverse effects Vietnam
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