Generation of IL-2-Dependent Cytolytic T Lymphocytes (CTLs) with Altered TCR Responses Derived from Antigen-Dependent CTL Clones

Ag-specific CD8+ CTL clones require TCR stimulation to respond to IL-2 for growth. Because IL-2 may be produced in the vicinity of CD8+ CTLs when Ag is limiting at the end of an immune response, we have examined the effect of culturing viral-specific CTL clones in IL-2 in the absence of antigenic st...

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Veröffentlicht in:The Journal of immunology (1950) 1999-06, Vol.162 (11), p.6466-6472
Hauptverfasser: Gullo, Charles A, Esser, Mark T, Fuller, Claudette L, Braciale, Vivian Lam
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Sprache:eng
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