FGF7/KGF triggers cell transformation and invasion on immortalised human prostatic epithelial PNT1A cells

Fibroblast growth factor 7 (FGF7/KGF) is synthesized exclusively by fibroblasts in normal tissues; it acts as a potent mitogen on epithelial cells, through interaction with the FGF7‐specific receptor FGFR2/IIIb. To examine the importance of this growth factor both to prostate physiology and to prost...

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Veröffentlicht in:	International journal of cancer 1999-07, Vol.82 (2), p.237-243
Hauptverfasser:	Ropiquet, Frédéric, Huguenin, Sandra, Villette, Jean‐Marie, Ronflé, Valérie, Le Brun, Gaëlle, Maitland, Norman J., Cussenot, Olivier, Fiet, Jean, Berthon, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Division - drug effects Cell Line, Transformed - drug effects Cell Survival - drug effects Cell Transformation, Neoplastic - chemically induced Disease Progression DNA, Neoplasm - genetics Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - pathology Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Fibroblast Growth Factors Growth Substances - toxicity Humans Male Medical sciences Metalloendopeptidases - analysis Mitogens - toxicity Neoplasm Invasiveness Nephrology. Urinary tract diseases Polymerase Chain Reaction Prostate - drug effects Prostate - enzymology Prostate - pathology Transfection Tumors of the urinary system Urinary tract. Prostate gland Urokinase-Type Plasminogen Activator - analysis
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