Incremental Conversion of Outer-Membrane Permeabilizers into Potent Antibiotics for Gram-Negative Bacteria

Cholic acid derivatives appended with amine groups have been prepared for use as permeabilizers of the outer membranes of Gram-negative bacteria. These compounds interact synergistically with antibiotics such as erythromycin and novobiocin to inhibit growth of Gram-negative bacteria. When a hydropho...

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Veröffentlicht in:	Journal of the American Chemical Society 1999-02, Vol.121 (5), p.931-940
Hauptverfasser:	Li, Chunhong, Budge, Loren P, Driscoll, Collin D, Willardson, Barry M, Allman, Glenn W, Savage, Paul B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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