Stat3 Cleavage by Caspases: IMPACT ON FULL-LENGTH Stat3 EXPRESSION, FRAGMENT FORMATION, AND TRANSCRIPTIONAL ACTIVITY

Stat3 and its isoforms belong to a family of cytoplasmic transcription factors that affect the synthesis of various proteins. Caspases are cysteinyl-aspartate proteases that function under apoptotic and non-apoptotic conditions. We now report that, in addition to transcriptional splicing, Stat3 frag...

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Veröffentlicht in:	The Journal of biological chemistry 2006-06, Vol.281 (26), p.17707-17717
Hauptverfasser:	Darnowski, James W, Goulette, Frederick A, Guan, Ying-jie, Chatterjee, Devasis, Yang, Zhong-Fa, Cousens, Leslie P, Chin, Y. Eugene
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Apoptosis - drug effects Apoptosis - physiology Caspase Inhibitors caspases Caspases - metabolism cells Cysteine Proteinase Inhibitors - pharmacology DNA fragmentation enzyme activity Enzyme Inhibitors - pharmacology gene expression Gene Expression Regulation - physiology HeLa Cells Humans luciferase Mutagenesis Peptide Fragments - genetics Peptide Fragments - metabolism protein synthesis proteinases proteins proteolysis signal transduction STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Staurosporine - pharmacology transcription factors transcriptional activation Transcriptional Activation - physiology
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