Toxicology and Pharmacokinetics of DTGM, a Fusion Toxin Consisting of a Truncated Diphtheria Toxin (DT388) Linked to Human Granulocyte-Macrophage Colony-Stimulating Factor, in Cynomolgus Monkeys

We developed a fusion toxin consisting of the catalytic and translocation domains of diphtheria toxin linked to human granulocyte-macrophage colony-stimulating factor (GM-CSF) (DTGM) for the treatment of patients with acute myeloid leukemia (AML). Our goal in this study was to determine the toxicity...

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Veröffentlicht in:	Toxicology and applied pharmacology 1999-07, Vol.158 (2), p.152-160
Hauptverfasser:	Hotchkiss, Charlotte E., Hall, Philip D., Cline, J.Mark, Willingham, Mark C., Kreitman, Robert J., Gardin, Jean, Latimer, Amy, Ramage, Jason, Feely, Theodore, DeLatte, Stephen, Tagge, Edward P., Frankel, Arthur E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia Animals Antineoplastic agents Biological and medical sciences Blood Cell Count - drug effects Bone Marrow Cells - drug effects Chemotherapy Colony-Stimulating Factors - immunology Colony-Stimulating Factors - pharmacology Corynebacterium diphtheriae diphtheria toxin Diphtheria Toxin - immunology Diphtheria Toxin - pharmacokinetics Diphtheria Toxin - toxicity Dose-Response Relationship, Drug Female fusion toxin GM-CSF Humans Immunoglobulin G - blood Macaca fascicularis Male Medical sciences Pharmacology. Drug treatments Time Factors
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