Ecdysone agonists - mechanism of action and application on Spodoptera species
Laboratory assays using artificial diet demonstrated that tebufenozide (RH‐5992) and the new structural analogue, RH‐2485 (proposed common name methoxyfenozide), possess strong ecdysone‐like activity against last‐instar larvae of the beet armyworm, Spodoptera exigua, and the cotton leafworm, Spodopt...
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| Veröffentlicht in: | Pesticide Science 1999-03, Vol.55 (3), p.386-389 |
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| creator | Smagghe, Guy Carton, Bert Wesemael, Wim Ishaaya, Isaac Tirry, Luc |
| description | Laboratory assays using artificial diet demonstrated that tebufenozide (RH‐5992) and the new structural analogue, RH‐2485 (proposed common name methoxyfenozide), possess strong ecdysone‐like activity against last‐instar larvae of the beet armyworm, Spodoptera exigua, and the cotton leafworm, Spodoptera littoralis, leading to precocious lethal moulting. LC50 values showed that the activity of RH‐2485 (0.38 mg AI litre−1) was about twice that of tebufenozide (0.60 mg AI litre−1) in S. exigua, whereas in S. littoralis respective LC50 values were 1.15 mg AI litre−1 and 9.51 mg AI litre−1. The retention‐fate curves of 14C‐radiolabelled ecdysone agonist could not explain the differential toxicity values between species and compounds. Ingestion of the oxidase inhibitor piperonyl butoxide (PB) synergized the toxicity of the ecdysone agonist, indicating the importance of oxidative detoxifcation in Spodoptera larvae, and may raise the possible use of PB as synergist for this group of insecticides, or for monitoring resistance due to increased oxidation.
© 1999 Society of Chemical Industry |
| doi_str_mv | 10.1002/(SICI)1096-9063(199903)55:3<386::AID-PS922>3.0.CO;2-5 |
| format | Article |
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© 1999 Society of Chemical Industry</description><subject>ecdysone agonist</subject><subject>enzyme synergism</subject><subject>insecticidal activity</subject><subject>Noctuidae</subject><subject>pharmacokinetic fate</subject><subject>RH-2485</subject><subject>Spodoptera</subject><subject>Spodoptera exigua</subject><subject>Spodoptera littoralis</subject><subject>tebufenozide</subject><issn>0031-613X</issn><issn>1526-498X</issn><issn>1096-9063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>K30</sourceid><recordid>eNqFkW1r2zAQgM3YYFm3_2AYjPaDs5POkqNsKxSv6QLtMpru5dshy_LmzrFcK6HNv59Sl3zoBoMD3R2nh-OeKPrAYMwA-NvD5TyfHzFQMlEg8ZAppQCPhJjie5zI6fRk_jH5slScH-MYxvniHU_Ek2i0__E0GgEgSyTDH8-jF95fA0CA4Ci6ODXl1rvWxvqna2u_9nESr6z5pUOxil0Va7OuXRvrtox11zW10fd1iGXnStetba9j31lTW_8yelbpxttXD-9B9HV2epV_Ss4XZ_P85DwxXKQ8saoSsgAJJZec66pgYmJkqotMTQqUuoCQ2zJNgUswpcEyRYm8BJ2myArEg-jNwO16d7Oxfk2r2hvbNLq1buOJZVyiTFUYfP1o8Npt-jbsRmySZUxknKe4X9P0zvveVtT19Ur3W2JAOwVEOwW0OyjtDkqDAhKCkIICoqCA7hWEBlC-IE4icL8N3Nu6sdu_oP9h_gs5NAI4GcBBmL3bg3X_m2SGmaDvn89oxtjl1cXskpb4B6rspxo</recordid><startdate>199903</startdate><enddate>199903</enddate><creator>Smagghe, Guy</creator><creator>Carton, Bert</creator><creator>Wesemael, Wim</creator><creator>Ishaaya, Isaac</creator><creator>Tirry, Luc</creator><general>John Wiley & Sons, Ltd</general><general>London :John Wiley & Sons Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7WH</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7SS</scope></search><sort><creationdate>199903</creationdate><title>Ecdysone agonists - mechanism of action and application on Spodoptera species</title><author>Smagghe, Guy ; 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Sci</addtitle><date>1999-03</date><risdate>1999</risdate><volume>55</volume><issue>3</issue><spage>386</spage><epage>389</epage><pages>386-389</pages><issn>0031-613X</issn><issn>1526-498X</issn><eissn>1096-9063</eissn><abstract>Laboratory assays using artificial diet demonstrated that tebufenozide (RH‐5992) and the new structural analogue, RH‐2485 (proposed common name methoxyfenozide), possess strong ecdysone‐like activity against last‐instar larvae of the beet armyworm, Spodoptera exigua, and the cotton leafworm, Spodoptera littoralis, leading to precocious lethal moulting. LC50 values showed that the activity of RH‐2485 (0.38 mg AI litre−1) was about twice that of tebufenozide (0.60 mg AI litre−1) in S. exigua, whereas in S. littoralis respective LC50 values were 1.15 mg AI litre−1 and 9.51 mg AI litre−1. The retention‐fate curves of 14C‐radiolabelled ecdysone agonist could not explain the differential toxicity values between species and compounds. Ingestion of the oxidase inhibitor piperonyl butoxide (PB) synergized the toxicity of the ecdysone agonist, indicating the importance of oxidative detoxifcation in Spodoptera larvae, and may raise the possible use of PB as synergist for this group of insecticides, or for monitoring resistance due to increased oxidation.
© 1999 Society of Chemical Industry</abstract><cop>London</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/(SICI)1096-9063(199903)55:3<386::AID-PS922>3.0.CO;2-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-613X |
| ispartof | Pesticide Science, 1999-03, Vol.55 (3), p.386-389 |
| issn | 0031-613X 1526-498X 1096-9063 |
| language | eng |
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| source | Periodicals Index Online; Access via Wiley Online Library |
| subjects | ecdysone agonist enzyme synergism insecticidal activity Noctuidae pharmacokinetic fate RH-2485 Spodoptera Spodoptera exigua Spodoptera littoralis tebufenozide |
| title | Ecdysone agonists - mechanism of action and application on Spodoptera species |
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