Crystal structure and improved antisense properties of 2'- O -(2-methoxyethyl)-RNA

2'- O -(2-Methoxyethyl)-RNA (MOE-RNA) is a nucleic acid analog with promising features for antisense applications. Compared with phosphorothioate DNA (PS-DNA), the MOE modification offers improved nuclease resistance, enhanced RNA affinity, improved cellular uptake and intestinal absorption, re...

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Veröffentlicht in:	Nature Structural Biology 1999-06, Vol.6 (6), p.535-539
Hauptverfasser:	Manoharan, Muthiah, Egli, Martin, Teplova, Marianna, Minasov, George, Tereshko, Valentina, Inamati, Gopal B, Cook, P. Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Base Sequence Biochemistry Biological Microscopy Biomedical and Life Sciences Crystallization Crystallography, X-Ray Drug Design Ethylenes - chemistry Ethylenes - metabolism Hydrogen Bonding letter Life Sciences Membrane Biology Models, Molecular Nucleic Acid Conformation Oligoribonucleotides Oxygen - metabolism Phosphates - metabolism Protein Structure RNA, Antisense - chemistry RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Antisense - therapeutic use Structure-Activity Relationship Water - metabolism
Online-Zugang:	Volltext
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