Possible role of duration of PKC-induced ERK activation in the effects of agonists and phorbol esters on DNA synthesis in panc-1 cells

Protein kinase C (PKC) and extracellular signal‐regulated kinase (ERK) have been implicated in the effects of regulatory peptides on proliferation. We studied how ERK was activated by PKC following regulatory peptide or phorbol ester stimulation and we also investigated the effect of ERK activation...

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Veröffentlicht in:	Journal of cellular biochemistry 2006-08, Vol.98 (6), p.1667-1680
Hauptverfasser:	Rácz, Gábor Z., Szűcs, Ákos, Szlávik, Vanda, Vág, János, Burghardt, Beáta, Elliott, Austin C., Varga, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation cholecystokinin Cholecystokinin - pharmacology DNA - metabolism extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism gene expression Humans neurotensin Neurotensin - pharmacology Panc-1 pancreas Pancreatic Neoplasms - metabolism Phorbol Esters - pharmacology proliferation protein kinase C Protein Kinase C - metabolism Protein Kinase C - physiology Protein Kinase C-epsilon - physiology Signal Transduction Tetradecanoylphorbol Acetate - pharmacology Transfection
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