The Estrogen-responsive B Box Protein Is a Novel Regulator of the Retinoid Signal

Retinoic acid (RA) induces growth arrest, cell death, and differentiation in many human cancer cells in vitro and has entered routine clinical use for the treatment of several human cancer types. One mechanism by which cancer cells evade retinoid-induced effects is through repression of retinoic aci...

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Veröffentlicht in:	The Journal of biological chemistry 2006-06, Vol.281 (26), p.18246-18256
Hauptverfasser:	Cheung, Belamy B., Bell, Jessica, Raif, Anna, Bohlken, Andrew, Yan, Joanne, Roediger, Ben, Poljak, Anne, Smith, Stewart, Lee, Michelle, Thomas, Wayne D., Kavallaris, Maria, Norris, Murray, Haber, Michelle, Liu, Hsiao-Lai, Zajchowski, Deborah, Marshall, Glenn M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Breast Neoplasms Cell Division - physiology Cell Line, Tumor DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - physiology Humans Lung Neoplasms Molecular Sequence Data Neoplasm Proteins - metabolism Neuroblastoma Nuclear Proteins - metabolism Promyelocytic Leukemia Protein Protein Structure, Tertiary Receptors, Retinoic Acid - metabolism RNA, Small Interfering Signal Transduction - physiology Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tretinoin - metabolism Tretinoin - pharmacology Tripartite Motif Proteins Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases
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