Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10

Mucosal tissues require constant immune surveillance to clear harmful pathogens while maintaining tolerance to self Ags. Regulatory T cells (Tregs) play a central role in this process and expression of alpha(E)beta(7) has been reported to define a subset of Tregs with tropism for inflamed tissues. H...

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Veröffentlicht in:	Journal of Immunology 2006-07, Vol.177 (1), p.593-603
Hauptverfasser:	Eksteen, Bertus, Miles, Alice, Curbishley, Stuart M, Tselepis, Chris, Grant, Allister J, Walker, Lucy S. K, Adams, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Ducts - immunology Bile Ducts - metabolism Bile Ducts - pathology Cells, Cultured Chemokines - biosynthesis Chemokines - metabolism Chemokines, CC Chemotaxis, Leukocyte - immunology Cholangitis, Sclerosing - immunology Cholangitis, Sclerosing - metabolism Cholangitis, Sclerosing - pathology Chronic Disease Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Forkhead Transcription Factors - biosynthesis Humans Immunity, Mucosal Inflammation Mediators - metabolism Inflammation Mediators - physiology Interleukin-1 - pharmacology Interleukin-10 - biosynthesis Interleukin-10 - metabolism Lipopolysaccharides - pharmacology Liver Cirrhosis, Biliary - immunology Liver Cirrhosis, Biliary - metabolism Liver Cirrhosis, Biliary - pathology Liver Diseases, Alcoholic - immunology Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - pathology Receptors, CCR10 Receptors, CCR7 Receptors, Chemokine - biosynthesis Receptors, CXCR3 T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Up-Regulation - immunology
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