1,2,3-Triazole Stabilized Neurotensin-Based Radiopeptidomimetics for Improved Tumor Targeting

Neurotensin (NT) is a regulatory peptide with nanomolar affinity toward NT receptors, which are overexpressed by different clinically relevant tumors. Its binding sequence, NT(8–13), represents a promising vector for the development of peptidic radiotracers for tumor imaging and therapy. The main dr...

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Veröffentlicht in:	Bioconjugate chemistry 2015-10, Vol.26 (10), p.2143-2152
Hauptverfasser:	Mascarin, Alba, Valverde, Ibai E, Vomstein, Sandra, Mindt, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Binding sites Biochemistry Chemistry Techniques, Synthetic Cycloaddition Reaction Female Gene expression Half-Life HT29 Cells Humans Isotope Labeling - methods Lutetium - chemistry Mice, Nude Molecular Targeted Therapy - methods Neurotensin - chemistry Peptide Fragments - chemistry Peptides Peptidomimetics - chemistry Peptidomimetics - pharmacokinetics Radioisotopes - chemistry Receptors, Neurotensin - metabolism Structure-Activity Relationship T cell receptors Tissue Distribution Triazoles - chemistry Tumors Xenograft Model Antitumor Assays
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