Comparative analysis of pathologic processes developing in mice housed in SPF vs non-SPF conditions and treated with cyclophosphamide and dsDNA preparation

In our earlier studies, we observed that when mice are treated with cyclophosphamide and fragmented exogenous dsDNA (18–30h post cytostatic treatment), they develop a very characteristic set of symptoms and 80–90% of such animals succumb within 6–25 days. This was called “delayed death” phenomenon,...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2015-10, Vol.211 (10), p.754-758
Hauptverfasser:	Dolgova, Evgeniya V., Efremov, Yaroslav R., Taranov, Oleg S., Potter, Ekaterina A., Nikolin, Valeriy P., Popova, Nelly A., Omigov, Vladimir V., Chernykh, Elena R., Proskurina, Anastasia S., Bogachev, Sergey S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - drug effects Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Cell Differentiation - drug effects Cell Lineage - drug effects Cells, Cultured Cyclophosphamide - pharmacology DNA - metabolism Double-stranded DNA Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Lymphoid progenitors Mice Mice, Inbred CBA Opportunistic infection SPF mice Systemic inflammation
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