Mechanisms of GDF-5 action during skeletal development

Mutations in GDF-5, a member of the TGF-beta superfamily, result in the autosomal recessive syndromes brachypod (bp) in mice and Hunter-Thompson and Grebe-type chondrodysplasias in humans. These syndromes are all characterised by the shortening of the appendicular skeleton and loss or abnormal devel...

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Veröffentlicht in:	Development (Cambridge) 1999-03, Vol.126 (6), p.1305-1315
Hauptverfasser:	Francis-West, P H, Abdelfattah, A, Chen, P, Allen, C, Parish, J, Ladher, R, Allen, S, MacPherson, S, Luyten, F P, Archer, C W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bone and Bones - embryology Bone Morphogenetic Proteins Cartilage - embryology Cell Aggregation - drug effects Cell Division - drug effects Chick Embryo Chondrogenesis - drug effects Cloning, Molecular DNA - analysis Extremities - embryology Glycosaminoglycans - analysis Growth Differentiation Factor 5 Growth Substances - genetics Growth Substances - metabolism Growth Substances - pharmacology Humerus - chemistry Limb Buds - embryology Molecular Sequence Data Recombinant Proteins - metabolism Sequence Homology, Amino Acid
Online-Zugang:	Volltext
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