Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm) : A new gene cluster on Xp22
We have identified a novel gene with homologies to the Drosophila Sex comb on midleg (Scm) gene from the short arm of the X chromosome. Scm is a member of the Polycomb group (PcG) genes, which encode transcriptional repressors essential for appropriate development in the fly and in mammals. The newl...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1999-05, Vol.58 (1), p.65-72 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | MONTINI, E BUCHNER, G SPALLUTO, C ANDOLFI, G CARUSO, A DUNNEN, J. T. D TRUMP, D ROCCHI, M BALLABIO, A FRANCO, B |
| description | We have identified a novel gene with homologies to the Drosophila Sex comb on midleg (Scm) gene from the short arm of the X chromosome. Scm is a member of the Polycomb group (PcG) genes, which encode transcriptional repressors essential for appropriate development in the fly and in mammals. The newly identified transcript named SCML2 (sex comb on midleg like-2, HGMW-approved symbol) is ubiquitously expressed and encodes a protein of 700 amino acids. SCML2 maps very close to the recently identified SCML1, revealing the presence of a new gene cluster in Xp22. The homology and map location identify SCML2 as a candidate gene for Xp22-linked developmental disorders, including the oral-facial-digital type I (OFDI) syndrome. A study of the SCML1-SCML2 cluster in primates indicates that the two genes are localized to the same region in Old World monkeys, New World monkeys, and prosimians, suggesting that the duplication event leading to the formation of the SCML cluster on Xp22 occurred before primate divergence. |
| doi_str_mv | 10.1006/geno.1999.5755 |
| format | Article |
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A study of the SCML1-SCML2 cluster in primates indicates that the two genes are localized to the same region in Old World monkeys, New World monkeys, and prosimians, suggesting that the duplication event leading to the formation of the SCML cluster on Xp22 occurred before primate divergence.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1999.5755</identifier><identifier>PMID: 10331946</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Blotting, Northern ; Cell Line ; DNA - chemistry ; DNA - genetics ; DNA, Complementary - chemistry ; DNA, Complementary - genetics ; DNA-Binding Proteins - genetics ; Drosophila - genetics ; Drosophila Proteins ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Genes - genetics ; Genes. Genome ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Multigene Family ; Polycomb-Group Proteins ; Primates ; Repressor Proteins - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Tissue Distribution ; Transcription Factors ; X Chromosome - genetics</subject><ispartof>Genomics (San Diego, Calif.), 1999-05, Vol.58 (1), p.65-72</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1843220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10331946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MONTINI, E</creatorcontrib><creatorcontrib>BUCHNER, G</creatorcontrib><creatorcontrib>SPALLUTO, C</creatorcontrib><creatorcontrib>ANDOLFI, G</creatorcontrib><creatorcontrib>CARUSO, A</creatorcontrib><creatorcontrib>DUNNEN, J. 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The homology and map location identify SCML2 as a candidate gene for Xp22-linked developmental disorders, including the oral-facial-digital type I (OFDI) syndrome. A study of the SCML1-SCML2 cluster in primates indicates that the two genes are localized to the same region in Old World monkeys, New World monkeys, and prosimians, suggesting that the duplication event leading to the formation of the SCML cluster on Xp22 occurred before primate divergence.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell Line</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>DNA, Complementary - chemistry</subject><subject>DNA, Complementary - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genes - genetics</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Polycomb-Group Proteins</subject><subject>Primates</subject><subject>Repressor Proteins - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tissue Distribution</subject><subject>Transcription Factors</subject><subject>X Chromosome - genetics</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1v2zAQgGGiaFA7bteOxQ1F0AKRwy9RVDbDaRIDDjrYQzaDIo-2AklURAlJp_71qrCDTLc8eA93hHxldM4oVVd7bMKc5Xk-T7M0_UCmjOo80Uqqj2RKtdZJlkoxIecxPlFKc6H5JzJhVAiWSzUlf1cOm770pTV9GRoIHjbLhzW_BAMRbWgcHIbaNDAuQjiEOlRhH4YIfYD-gHDThRjaQ1kZ2OAr2FAXMGbq0lW4hx8bW_-Ea1hAgy_HhK2G2GP3Hz22nH8mZ95UEb-c5oxsb39tl_fJ-vfdarlYJy1XWZ8oldFCSi8YQ-ULmxnKueIoUDrlHXKPmmYp1wJTSXnhrUfnbFFYIZlDMSMXx2zbhecBY7-ry2ixqkyD4zU7lvGUZYyP8NsJDkWNbtd2ZW26P7u3j43g-wmYaE3lO9PYMr47LQXnVPwDN9x5-g</recordid><startdate>19990515</startdate><enddate>19990515</enddate><creator>MONTINI, E</creator><creator>BUCHNER, G</creator><creator>SPALLUTO, C</creator><creator>ANDOLFI, G</creator><creator>CARUSO, A</creator><creator>DUNNEN, J. T. D</creator><creator>TRUMP, D</creator><creator>ROCCHI, M</creator><creator>BALLABIO, A</creator><creator>FRANCO, B</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19990515</creationdate><title>Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm) : A new gene cluster on Xp22</title><author>MONTINI, E ; BUCHNER, G ; SPALLUTO, C ; ANDOLFI, G ; CARUSO, A ; DUNNEN, J. T. D ; TRUMP, D ; ROCCHI, M ; BALLABIO, A ; FRANCO, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p267t-6670b44f311e6fbc7a02262e3e4d6fde2fe8075283e5402bfcfeddcbbc341de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell Line</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>DNA, Complementary - chemistry</topic><topic>DNA, Complementary - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genes - genetics</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Polycomb-Group Proteins</topic><topic>Primates</topic><topic>Repressor Proteins - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tissue Distribution</topic><topic>Transcription Factors</topic><topic>X Chromosome - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONTINI, E</creatorcontrib><creatorcontrib>BUCHNER, G</creatorcontrib><creatorcontrib>SPALLUTO, C</creatorcontrib><creatorcontrib>ANDOLFI, G</creatorcontrib><creatorcontrib>CARUSO, A</creatorcontrib><creatorcontrib>DUNNEN, J. T. 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D</au><au>TRUMP, D</au><au>ROCCHI, M</au><au>BALLABIO, A</au><au>FRANCO, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm) : A new gene cluster on Xp22</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1999-05-15</date><risdate>1999</risdate><volume>58</volume><issue>1</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have identified a novel gene with homologies to the Drosophila Sex comb on midleg (Scm) gene from the short arm of the X chromosome. Scm is a member of the Polycomb group (PcG) genes, which encode transcriptional repressors essential for appropriate development in the fly and in mammals. The newly identified transcript named SCML2 (sex comb on midleg like-2, HGMW-approved symbol) is ubiquitously expressed and encodes a protein of 700 amino acids. SCML2 maps very close to the recently identified SCML1, revealing the presence of a new gene cluster in Xp22. The homology and map location identify SCML2 as a candidate gene for Xp22-linked developmental disorders, including the oral-facial-digital type I (OFDI) syndrome. A study of the SCML1-SCML2 cluster in primates indicates that the two genes are localized to the same region in Old World monkeys, New World monkeys, and prosimians, suggesting that the duplication event leading to the formation of the SCML cluster on Xp22 occurred before primate divergence.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>10331946</pmid><doi>10.1006/geno.1999.5755</doi><tpages>8</tpages></addata></record> |
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| subjects | Amino Acid Sequence Animals Biological and medical sciences Blotting, Northern Cell Line DNA - chemistry DNA - genetics DNA, Complementary - chemistry DNA, Complementary - genetics DNA-Binding Proteins - genetics Drosophila - genetics Drosophila Proteins Female Fundamental and applied biological sciences. Psychology Gene Expression Genes - genetics Genes. Genome Humans In Situ Hybridization, Fluorescence Male Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family Polycomb-Group Proteins Primates Repressor Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, DNA Sequence Homology, Amino Acid Tissue Distribution Transcription Factors X Chromosome - genetics |
| title | Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm) : A new gene cluster on Xp22 |
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