Pulmonary toxicity caused by acute exposure to mercury vapor is enhanced in metallothionein-null mice

This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg 0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg 0 at 6.6 to 7.5 mg m 3 for 4 hr each day for 3 consecutive days. This dosing pr...

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Veröffentlicht in:	Life sciences (1973) 1999-04, Vol.64 (20), p.1861-1867
Hauptverfasser:	Yoshida, Minoru, Satoh, Masahiko, Shimada, Akinori, Yasutake, Akira, Sumi, Yawara, Tohyama, Chiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Blood Urea Nitrogen Chromatography, Gel Creatinine - blood Lung - drug effects Lung - metabolism Lung - pathology Lung Diseases - chemically induced Lung Diseases - metabolism Lung Diseases - mortality Lung Diseases - pathology Mercury - metabolism Mercury - toxicity mercury vapor metallothionein Metallothionein - deficiency Metallothionein - genetics Metallothionein - metabolism Metallothionein - physiology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic pulmonary damage Radioimmunoassay Survival Rate transgenic mice Volatilization
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