Circadian clocks as modulators of metabolic comorbidity in psychiatric disorders
© Springer Science+Business Media New York 2015 Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regul...
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| Veröffentlicht in: | Current psychiatry reports 2015-12, Vol.17 (12), p.98-98, Article 98 |
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| container_title | Current psychiatry reports |
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| creator | Barandas, Rita Landgraf, Dominic McCarthy, Michael J. Welsh, David K. |
| description | © Springer Science+Business Media New York 2015
Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
Supported by a Veterans Affairs Merit Award (1I01BX001146) and a NARSAD Young Investigator Award to David K. Welsh. |
| doi_str_mv | 10.1007/s11920-015-0637-2 |
| format | Article |
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Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
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Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
Supported by a Veterans Affairs Merit Award (1I01BX001146) and a NARSAD Young Investigator Award to David K. Welsh.</description><subject>Brain - metabolism</subject><subject>Chronobiology Disorders - metabolism</subject><subject>Chronobiology Disorders - psychology</subject><subject>Circadian Clocks - physiology</subject><subject>Circadian rhythm</subject><subject>Comorbidity</subject><subject>Depression</subject><subject>Dopamine - metabolism</subject><subject>Glucocorticoids - metabolism</subject><subject>Humans</subject><subject>Hypothalamic Hormones - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanins - metabolism</subject><subject>Mental disorders</subject><subject>Mental Disorders - metabolism</subject><subject>Mental Disorders - physiopathology</subject><subject>Metabolic syndrome</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Pituitary Hormones - metabolism</subject><subject>Psychiatric disorders</subject><subject>Psychiatry</subject><subject>Reward</subject><subject>Section Editor</subject><subject>Sleep Disorders (P Gehrman</subject><subject>Topical Collection on Sleep Disorders</subject><issn>1523-3812</issn><issn>1535-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1r3DAQhkVoyG4-fkAvxSWXXJxq9GGtj2XJFywkh_QstJLcamtbW40d2H8fGact5BAY0MA87zviHUI-A70GStU3BKgZLSnIklZcleyILEFyWUIl5KepZ7zkK2ALcoq4o5RRumInZMEqseKwgiV5WodkjQumL2wb7W8sDBZddGNrhpiwiE3R-cFsYxtsYWMX0za4MByK0Bd7PNhfwQwpj1zAmJxPeE6OG9Oiv3h7z8iP25vn9X25ebx7WH_flFZSNZRCgagbaKQV3FlFuZVKelNxTlVjbS1Z4yrvTc1lY0VdZd5bx2XF_VZ4JvkZuZp99yn-GT0Ougtofdua3scRNSgm6VQqo5fv0F0cU59_p5mgVQ1KAc8UzJRNETH5Ru9T6Ew6aKB6ilvPcesct57i1ixrvrw5j9vOu3-Kv_lmgM0A5lH_06f_qz9y_TqL8mXMXif_EnAwk0JI0JKLfNZXjGGUrw</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Barandas, Rita</creator><creator>Landgraf, Dominic</creator><creator>McCarthy, Michael J.</creator><creator>Welsh, David K.</creator><general>Springer Nature</general><general>Springer US</general><general>Springer Nature B.V</general><scope>RCLKO</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Circadian clocks as modulators of metabolic comorbidity in psychiatric disorders</title><author>Barandas, Rita ; 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Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
Supported by a Veterans Affairs Merit Award (1I01BX001146) and a NARSAD Young Investigator Award to David K. Welsh.</abstract><cop>New York</cop><pub>Springer Nature</pub><pmid>26483181</pmid><doi>10.1007/s11920-015-0637-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Brain - metabolism Chronobiology Disorders - metabolism Chronobiology Disorders - psychology Circadian Clocks - physiology Circadian rhythm Comorbidity Depression Dopamine - metabolism Glucocorticoids - metabolism Humans Hypothalamic Hormones - metabolism Medicine Medicine & Public Health Melanins - metabolism Mental disorders Mental Disorders - metabolism Mental Disorders - physiopathology Metabolic syndrome Metabolism Obesity Pituitary Hormones - metabolism Psychiatric disorders Psychiatry Reward Section Editor Sleep Disorders (P Gehrman Topical Collection on Sleep Disorders |
| title | Circadian clocks as modulators of metabolic comorbidity in psychiatric disorders |
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