Expression of pannexin1 in the CNS of adult mouse: Cellular localization and effect of 4-aminopyridine-induced seizures

The expression pattern of pannexin1, a gene coding for a protein that forms gap junction channels, was studied as both mRNA and protein in the CNS of adult mouse. Pannexin1 was widely expressed in the CNS by neuronal cell types but not glial cells, except for Bergmann glial cells of the cerebellar c...

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Veröffentlicht in:	Neuroscience 2006-01, Vol.141 (1), p.167-178
Hauptverfasser:	Zappalà, A., Cicero, D., Serapide, M.F., Paz, C., Catania, M.V., Falchi, M., Parenti, R., Pantò, M.R., La Delia, F., Cicirata, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine Animals Biological and medical sciences Blotting, Western - methods brain Central Nervous System - metabolism Connexins - metabolism Eye Proteins - metabolism Fundamental and applied biological sciences. Psychology Gap Junction delta-2 Protein Gene Expression - drug effects Gene Expression - physiology HeLa Cells Humans Immunohistochemistry - methods Mice mouse Nerve Tissue Proteins - metabolism neurons pannexin Parvalbumins - metabolism Potassium Channel Blockers Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Seizures - chemically induced Seizures - metabolism Time Factors Transfection - methods Vertebrates: nervous system and sense organs
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