Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension

Many effects of nitrite and nitrate are attributed to increased circulating concentrations of nitrite, ultimately converted into nitric oxide (NO•) in the circulation or in tissues by mechanisms associated with nitrite reductase activity. However, nitrite generates NO• , nitrous anhydride, and other...

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Veröffentlicht in:	Free radical biology & medicine 2015-10, Vol.87, p.252-262
Hauptverfasser:	Pinheiro, Lucas C., Amaral, Jefferson H., Ferreira, Graziele C., Portella, Rafael L., Ceron, Carla S., Montenegro, Marcelo F., Toledo, Jose Carlos, Tanus-Santos, Jose E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - administration & dosage Antioxidants - administration & dosage Antioxidants - metabolism Disease Models, Animal Free Radicals - metabolism Gastric Mucosa - drug effects Gastric Mucosa - metabolism Humans Hypertension Hypertension, Renovascular - drug therapy Hypertension, Renovascular - metabolism Hypertension, Renovascular - pathology Nitrates Nitrites Nitrites - metabolism Nitrosation Omeprazole Rats S-Nitrosothiols S-Nitrosothiols - metabolism Sodium Nitrite - administration & dosage
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