Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

Perfluoroalkyl acids (PFAAs) are a group of widely used anthropogenic compounds. As one of the most dominant PFAAs, perfluorooctanoic acid (PFOA) has been suggested to induce hepatotoxicity and several other toxicological effects. However, details on the mechanisms for PFOA-induced hepatotoxicity st...

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Veröffentlicht in:	Free radical biology & medicine 2015-10, Vol.87, p.300-311
Hauptverfasser:	Yan, Shengmin, Zhang, Hongxia, Wang, Jianshe, Zheng, Fei, Dai, Jiayin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Caprylates - toxicity Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Endoplasmic Reticulum Stress - drug effects Fluorocarbons - toxicity Hep G2 Cells Hepatotoxicity Humans Lipid metabolism Lipid Metabolism - drug effects Liver - drug effects Liver - metabolism Liver - pathology Liver injury Mice Oxidative stress Phenylbutyrates - administration & dosage Reactive Oxygen Species - metabolism Signal Transduction - drug effects Sodium 4-phenylbutyrate Unfolded Protein Response - drug effects
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