Mindin deficiency protects the liver against ischemia/reperfusion injury

Background & Aims Hepatic ischemia/reperfusion (I/R) injury often occurs during liver surgery and may cause liver failure. Our previous studies revealed that Mindin is involved in the pathogenesis of ischemic stroke. However, the function of Mindin in hepatic I/R injury remains unknown. Methods...

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Veröffentlicht in:	Journal of hepatology 2015-11, Vol.63 (5), p.1198-1211
Hauptverfasser:	Sun, Peng, Zhang, Peng, Wang, Pi-Xiao, Zhu, Li-Hua, Du, Yibao, Tian, Song, Zhu, Xueyong, Li, Hongliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Apoptosis Blotting, Western Cell death Cells, Cultured Disease Models, Animal Extracellular Matrix Proteins - deficiency Extracellular Matrix Proteins - genetics Flow Cytometry Gastroenterology and Hepatology Gene Expression Regulation Hepatic ischemia/reperfusion In Situ Nick-End Labeling Inflammation Liver - blood supply Liver - metabolism Liver - pathology Liver Diseases - etiology Liver Diseases - genetics Liver Diseases - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mindin Real-Time Polymerase Chain Reaction Regeneration Reperfusion Injury - complications Reperfusion Injury - genetics Reperfusion Injury - metabolism RNA - genetics Signal Transduction
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