In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats

The aim in this study is to observe the hippocampal redox state during kainic-acid (KA)-induced seizure status, and examine the effect of systemic preinjection of anticonvulsant zonisamide (ZNS) on the hippocampal redox. To perform under a freely moving state, in vivo microdialysis method was applie...

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Veröffentlicht in:	Neurochemical research 2005-09, Vol.30 (9), p.1117-1121
Hauptverfasser:	Ueda, Yuto, Doi, Taku, Tokumaru, Jun, Nakajima, Akira, Nagatomo, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - metabolism Anticonvulsants - pharmacology Electron Spin Resonance Spectroscopy Hippocampus - chemistry Hippocampus - drug effects Hippocampus - metabolism Isoxazoles - metabolism Isoxazoles - pharmacology Kainic Acid - toxicity Male Microdialysis Nitrogen Oxides - metabolism Oxidation-Reduction Rats Rats, Wistar Seizures - chemically induced
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