Impaired Function of Dendritic Cells Circulating in Patients Infected with Hepatitis C Virus Who Have Persistently Normal Alanine Aminotransferase Levels
Hepatitis C virus (HCV) induces chronic liver disease in hosts which can eventually progresses to liver cirrhosis and hepatocellular carcinoma. However, progression of liver disease is slower in patients with persistently normal levels of alanine aminotransferase (ALT) than in those with active hepa...
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| Veröffentlicht in: | Intervirology 2006, Vol.49 (1-2), p.58-63 |
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| creator | Kanto, Tatsuya Inoue, Michiyo Miyazaki, Masanori Itose, Ichiyo Miyatake, Hideki Sakakibara, Mitsuru Yakushijin, Takayuki Kaimori, Aki Oki, Chika Hiramatsu, Naoki Kasahara, Akinori Hayashi, Norio |
| description | Hepatitis C virus (HCV) induces chronic liver disease in hosts which can eventually progresses to liver cirrhosis and hepatocellular carcinoma. However, progression of liver disease is slower in patients with persistently normal levels of alanine aminotransferase (ALT) than in those with active hepatitis. Although distinct immune responses against HCV have been proposed in asymptomatic infection, the role of circulating dendritic cells (DC) in the pathogenesis of these patients remains obscure. To address this issue, we compared the number and function of myeloid DC (MDC) and plasmacytoid DC (PDC) between uninfected individuals and HCV-infected patients with or without elevated ALT levels. Numbers of DC and DC progenitors were significantly lower in patients with chronic active hepatitis than in control subjects. However, no differences were found in the number of DC between normal controls and HCV-infected patients with persistently normal ALT levels. MDC from patients with active hepatitis were less able to polarize naive CD4 T cells into the Th1 phenotype, while their MDC and PDC primed more CD4 T cells producing IL-10 than those from normal controls. Such dysfunction of DC was also observed in patients with persistently normal ALT levels. In conclusion, circulating DC decrease in number predominantly in HCV-infected patients with active hepatitis, and the function of DC is impaired even in those with normal ALT levels. |
| doi_str_mv | 10.1159/000087264 |
| format | Article |
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However, progression of liver disease is slower in patients with persistently normal levels of alanine aminotransferase (ALT) than in those with active hepatitis. Although distinct immune responses against HCV have been proposed in asymptomatic infection, the role of circulating dendritic cells (DC) in the pathogenesis of these patients remains obscure. To address this issue, we compared the number and function of myeloid DC (MDC) and plasmacytoid DC (PDC) between uninfected individuals and HCV-infected patients with or without elevated ALT levels. Numbers of DC and DC progenitors were significantly lower in patients with chronic active hepatitis than in control subjects. However, no differences were found in the number of DC between normal controls and HCV-infected patients with persistently normal ALT levels. MDC from patients with active hepatitis were less able to polarize naive CD4 T cells into the Th1 phenotype, while their MDC and PDC primed more CD4 T cells producing IL-10 than those from normal controls. Such dysfunction of DC was also observed in patients with persistently normal ALT levels. In conclusion, circulating DC decrease in number predominantly in HCV-infected patients with active hepatitis, and the function of DC is impaired even in those with normal ALT levels.</description><identifier>ISSN: 0300-5526</identifier><identifier>ISBN: 9783805580175</identifier><identifier>ISBN: 3805580177</identifier><identifier>EISSN: 1423-0100</identifier><identifier>EISBN: 3318012807</identifier><identifier>EISBN: 9783318012804</identifier><identifier>DOI: 10.1159/000087264</identifier><identifier>PMID: 16166790</identifier><identifier>CODEN: IVRYAK</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Alanine Transaminase - blood ; CD4-Positive T-Lymphocytes - immunology ; Cell Count ; Cells, Cultured ; Dendritic Cells - cytology ; Dendritic Cells - immunology ; Female ; Hepatitis C - blood ; Hepatitis C - immunology ; Hepatitis C - physiopathology ; Hepatitis C virus ; Humans ; Lymphocyte Activation ; Male ; Myeloid Cells - cytology ; Pathophysiology ; Plasma Cells - cytology ; Stem Cells - cytology ; Th1 Cells - immunology ; Th2 Cells - immunology</subject><ispartof>Intervirology, 2006, Vol.49 (1-2), p.58-63</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>Copyright (c) 2006 S. Karger AG, Basel.</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-768d78c2a0c445c55fbbdbc6a06bee7b62f711276c042ce6a950e8f6711d97ed3</citedby><cites>FETCH-LOGICAL-c392t-768d78c2a0c445c55fbbdbc6a06bee7b62f711276c042ce6a950e8f6711d97ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16166790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanto, Tatsuya</creatorcontrib><creatorcontrib>Inoue, Michiyo</creatorcontrib><creatorcontrib>Miyazaki, Masanori</creatorcontrib><creatorcontrib>Itose, Ichiyo</creatorcontrib><creatorcontrib>Miyatake, Hideki</creatorcontrib><creatorcontrib>Sakakibara, Mitsuru</creatorcontrib><creatorcontrib>Yakushijin, Takayuki</creatorcontrib><creatorcontrib>Kaimori, Aki</creatorcontrib><creatorcontrib>Oki, Chika</creatorcontrib><creatorcontrib>Hiramatsu, Naoki</creatorcontrib><creatorcontrib>Kasahara, Akinori</creatorcontrib><creatorcontrib>Hayashi, Norio</creatorcontrib><title>Impaired Function of Dendritic Cells Circulating in Patients Infected with Hepatitis C Virus Who Have Persistently Normal Alanine Aminotransferase Levels</title><title>Intervirology</title><addtitle>Intervirology</addtitle><description>Hepatitis C virus (HCV) induces chronic liver disease in hosts which can eventually progresses to liver cirrhosis and hepatocellular carcinoma. However, progression of liver disease is slower in patients with persistently normal levels of alanine aminotransferase (ALT) than in those with active hepatitis. Although distinct immune responses against HCV have been proposed in asymptomatic infection, the role of circulating dendritic cells (DC) in the pathogenesis of these patients remains obscure. To address this issue, we compared the number and function of myeloid DC (MDC) and plasmacytoid DC (PDC) between uninfected individuals and HCV-infected patients with or without elevated ALT levels. Numbers of DC and DC progenitors were significantly lower in patients with chronic active hepatitis than in control subjects. However, no differences were found in the number of DC between normal controls and HCV-infected patients with persistently normal ALT levels. MDC from patients with active hepatitis were less able to polarize naive CD4 T cells into the Th1 phenotype, while their MDC and PDC primed more CD4 T cells producing IL-10 than those from normal controls. Such dysfunction of DC was also observed in patients with persistently normal ALT levels. In conclusion, circulating DC decrease in number predominantly in HCV-infected patients with active hepatitis, and the function of DC is impaired even in those with normal ALT levels.</description><subject>Alanine Transaminase - blood</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cell Count</subject><subject>Cells, Cultured</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - immunology</subject><subject>Female</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - physiopathology</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Myeloid Cells - cytology</subject><subject>Pathophysiology</subject><subject>Plasma Cells - cytology</subject><subject>Stem Cells - cytology</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><issn>0300-5526</issn><issn>1423-0100</issn><isbn>9783805580175</isbn><isbn>3805580177</isbn><isbn>3318012807</isbn><isbn>9783318012804</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1v1DAQhs2X6HbpgTMSsnpA4rAwtmM7Oa6Wll1pBT3wcYwcZ9K6JM7Wdor6U_i3uNpVkbh0Lh55nvcdjWYIec3gA2Oy-gg5Ss1V8YQcC8FKYLwE_ZTMWMHFAhjAM3JS6VKUIGWuavmczEAALKTk6ogcx3idLQQT8JIcMcWU0hXMyJ_NsDMuYEvPJ2-TGz0dO_oJfRtccpausO8jXblgp94k5y-p8_QiZ-hTpBvfoU1Z_NulK7rGXS4kl3n6w4Up0p9XI12bW6QXGKKLKYv6O_plDIPp6bI33nmky8H5MQXjY4fBRKRbvMU-viIvOtNHPDm8c_L9_Ozbar3Yfv28WS23CysqnhZala0uLTdgi0JaKbumaRurDKgGUTeKd5oxrpWFgltUppKAZafyZ1tpbMWcvNv77sJ4M2FM9eCizWMbj-MUaw2sLJSER0EOFVOVKh4FmeZCq7y3OTn9D7wep-DztNmsYEpwdd_2_R6yYYwxYFfvghtMuKsZ1Pe3UT_cRmbfHgynZsD2H3nYdwbe7IFfJlxieAD28r_t3rjR</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Kanto, Tatsuya</creator><creator>Inoue, Michiyo</creator><creator>Miyazaki, Masanori</creator><creator>Itose, Ichiyo</creator><creator>Miyatake, Hideki</creator><creator>Sakakibara, Mitsuru</creator><creator>Yakushijin, Takayuki</creator><creator>Kaimori, Aki</creator><creator>Oki, Chika</creator><creator>Hiramatsu, Naoki</creator><creator>Kasahara, Akinori</creator><creator>Hayashi, Norio</creator><general>S. 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Academic</collection><jtitle>Intervirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanto, Tatsuya</au><au>Inoue, Michiyo</au><au>Miyazaki, Masanori</au><au>Itose, Ichiyo</au><au>Miyatake, Hideki</au><au>Sakakibara, Mitsuru</au><au>Yakushijin, Takayuki</au><au>Kaimori, Aki</au><au>Oki, Chika</au><au>Hiramatsu, Naoki</au><au>Kasahara, Akinori</au><au>Hayashi, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Function of Dendritic Cells Circulating in Patients Infected with Hepatitis C Virus Who Have Persistently Normal Alanine Aminotransferase Levels</atitle><jtitle>Intervirology</jtitle><addtitle>Intervirology</addtitle><date>2006</date><risdate>2006</risdate><volume>49</volume><issue>1-2</issue><spage>58</spage><epage>63</epage><pages>58-63</pages><issn>0300-5526</issn><eissn>1423-0100</eissn><isbn>9783805580175</isbn><isbn>3805580177</isbn><eisbn>3318012807</eisbn><eisbn>9783318012804</eisbn><coden>IVRYAK</coden><abstract>Hepatitis C virus (HCV) induces chronic liver disease in hosts which can eventually progresses to liver cirrhosis and hepatocellular carcinoma. However, progression of liver disease is slower in patients with persistently normal levels of alanine aminotransferase (ALT) than in those with active hepatitis. Although distinct immune responses against HCV have been proposed in asymptomatic infection, the role of circulating dendritic cells (DC) in the pathogenesis of these patients remains obscure. To address this issue, we compared the number and function of myeloid DC (MDC) and plasmacytoid DC (PDC) between uninfected individuals and HCV-infected patients with or without elevated ALT levels. Numbers of DC and DC progenitors were significantly lower in patients with chronic active hepatitis than in control subjects. However, no differences were found in the number of DC between normal controls and HCV-infected patients with persistently normal ALT levels. MDC from patients with active hepatitis were less able to polarize naive CD4 T cells into the Th1 phenotype, while their MDC and PDC primed more CD4 T cells producing IL-10 than those from normal controls. Such dysfunction of DC was also observed in patients with persistently normal ALT levels. In conclusion, circulating DC decrease in number predominantly in HCV-infected patients with active hepatitis, and the function of DC is impaired even in those with normal ALT levels.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>16166790</pmid><doi>10.1159/000087264</doi><tpages>6</tpages></addata></record> |
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| ispartof | Intervirology, 2006, Vol.49 (1-2), p.58-63 |
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| source | Karger Journals; MEDLINE |
| subjects | Alanine Transaminase - blood CD4-Positive T-Lymphocytes - immunology Cell Count Cells, Cultured Dendritic Cells - cytology Dendritic Cells - immunology Female Hepatitis C - blood Hepatitis C - immunology Hepatitis C - physiopathology Hepatitis C virus Humans Lymphocyte Activation Male Myeloid Cells - cytology Pathophysiology Plasma Cells - cytology Stem Cells - cytology Th1 Cells - immunology Th2 Cells - immunology |
| title | Impaired Function of Dendritic Cells Circulating in Patients Infected with Hepatitis C Virus Who Have Persistently Normal Alanine Aminotransferase Levels |
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