Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine

Abstract The aim of the present study was to assess alterations in DNA methylation and hydroxymethylation during aging in cerebellar Purkinje cells and to determine the effects of putatively preventative measures to such age-related changes. Using immunohistochemical techniques, 5-methylcytosine (5-...

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Veröffentlicht in:	Neurobiology of aging 2015-11, Vol.36 (11), p.3079-3089
Hauptverfasser:	Lardenoije, Roy, van den Hove, Daniël L.A, Vaessen, Thomas S.J, Iatrou, Artemis, Meuwissen, Koen P.V, van Hagen, Britt T.J, Kenis, Gunter, Steinbusch, Harry W.M, Schmitz, Christoph, Rutten, Bart P.F
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Aging Animals Antioxidant overexpression Caloric Restriction Cytosine - analogs & derivatives Cytosine - metabolism DNA hydroxymethylation DNA methylation DNA Methylation - genetics Epigenesis, Genetic - physiology Gene Expression Immunohistochemistry - methods Internal Medicine Mice, Inbred C57BL Neurology Purkinje cells Purkinje Cells - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - physiology Superoxide Dismutase-1
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