Evaluation of the change in sphingolipids in the human multiple myeloma cell line U266 and gastric cancer cell line MGC-803 treated with arsenic trioxide

•An HPLC-ESI–MS/MS method was applied to investigate the changes in sphingolipids.•Arsenic trioxide (As2O3) was used to treat human U266 and MGC-803 cells.•The distributions of sphingolipids are different in the human U266 and MGC-803 cells.•The levels of Hex2Cer in human U266 cells decreased when t...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-11, Vol.1004, p.98-107
Hauptverfasser:	Zou, Jianhua, Ma, Xiaoqiong, Zhang, Guangji, Shen, Li, Zhou, Liting, Yu, Yu, Zhu, Fanfan, Chen, Zhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenic trioxide Arsenicals - pharmacology Cell Line, Tumor Chromatography, High Pressure Liquid HPLC-ESI–MS/MS Human gastric cancer cell line MGC-803 Human multiple myeloma cell line U266 Humans Multiple Myeloma - metabolism Multiple Myeloma - pathology Oxides - pharmacology Spectrometry, Mass, Electrospray Ionization Sphingolipids Sphingolipids - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tandem Mass Spectrometry
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