A history of drug development in four acts
•The future of pharmaceutical discovery is unclear in light of unique trends in marketing and R&D allocations.•Slowing investment in early-stage discovery raises concerns about pipeline sustainability.•Decreasing NIH funding threatens the future of academia as a source of innovation.
Gespeichert in:
| Veröffentlicht in: | Drug discovery today 2015-10, Vol.20 (10), p.1163-1168 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1168 |
|---|---|
| container_issue | 10 |
| container_start_page | 1163 |
| container_title | Drug discovery today |
| container_volume | 20 |
| creator | Kinch, Michael S. Hoyer, Denton |
| description | •The future of pharmaceutical discovery is unclear in light of unique trends in marketing and R&D allocations.•Slowing investment in early-stage discovery raises concerns about pipeline sustainability.•Decreasing NIH funding threatens the future of academia as a source of innovation. |
| doi_str_mv | 10.1016/j.drudis.2015.04.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1723756359</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1359644615001476</els_id><sourcerecordid>1723756359</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-6c796f2067acc15a01dc7e3b556dc389b00cbae5581165a63663da5c4f62efe73</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6D0R6FKE1aZqkvQjL4hcseNFzSJOpZmmbNWkX9t-bpatHTzOHZ-blfRC6JjgjmPD7TWb8aGzIckxYhosMY3qC5qQUZcpKmp_GnbIq5UXBZ-gihA3GJK8YP0eznFW4ZELM0d0y-bJhcH6fuCaJHz8TAzto3baDfkhsnzRu9InSQ7hEZ41qA1wd5wJ9PD2-r17S9dvz62q5TjUtyZByLSre5JgLpTVhChOjBdCaMW4iUdUY61oBYyUhnClOOadGMV00PIcGBF2g2-nv1rvvEcIgOxs0tK3qwY1BEpFTwXjsFtFiQrV3IXho5NbbTvm9JFgeLMmNnCzJgyWJCxktxbObY8JYd2D-jn61ROBhAiD23FnwMmgLvQZjPehBGmf_T_gB0cZ5HQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1723756359</pqid></control><display><type>article</type><title>A history of drug development in four acts</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Kinch, Michael S. ; Hoyer, Denton</creator><creatorcontrib>Kinch, Michael S. ; Hoyer, Denton</creatorcontrib><description>•The future of pharmaceutical discovery is unclear in light of unique trends in marketing and R&D allocations.•Slowing investment in early-stage discovery raises concerns about pipeline sustainability.•Decreasing NIH funding threatens the future of academia as a source of innovation.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2015.04.003</identifier><identifier>PMID: 25908577</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Drug Approval - history ; Drug Design ; Drug Discovery - history ; Drug Discovery - legislation & jurisprudence ; History, 20th Century ; History, 21st Century ; Humans ; Legislation, Drug - history ; United States ; United States Food and Drug Administration</subject><ispartof>Drug discovery today, 2015-10, Vol.20 (10), p.1163-1168</ispartof><rights>2015 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c381t-6c796f2067acc15a01dc7e3b556dc389b00cbae5581165a63663da5c4f62efe73</cites><orcidid>0000-0003-3939-3756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drudis.2015.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25908577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinch, Michael S.</creatorcontrib><creatorcontrib>Hoyer, Denton</creatorcontrib><title>A history of drug development in four acts</title><title>Drug discovery today</title><addtitle>Drug Discov Today</addtitle><description>•The future of pharmaceutical discovery is unclear in light of unique trends in marketing and R&D allocations.•Slowing investment in early-stage discovery raises concerns about pipeline sustainability.•Decreasing NIH funding threatens the future of academia as a source of innovation.</description><subject>Drug Approval - history</subject><subject>Drug Design</subject><subject>Drug Discovery - history</subject><subject>Drug Discovery - legislation & jurisprudence</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Legislation, Drug - history</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0R6FKE1aZqkvQjL4hcseNFzSJOpZmmbNWkX9t-bpatHTzOHZ-blfRC6JjgjmPD7TWb8aGzIckxYhosMY3qC5qQUZcpKmp_GnbIq5UXBZ-gihA3GJK8YP0eznFW4ZELM0d0y-bJhcH6fuCaJHz8TAzto3baDfkhsnzRu9InSQ7hEZ41qA1wd5wJ9PD2-r17S9dvz62q5TjUtyZByLSre5JgLpTVhChOjBdCaMW4iUdUY61oBYyUhnClOOadGMV00PIcGBF2g2-nv1rvvEcIgOxs0tK3qwY1BEpFTwXjsFtFiQrV3IXho5NbbTvm9JFgeLMmNnCzJgyWJCxktxbObY8JYd2D-jn61ROBhAiD23FnwMmgLvQZjPehBGmf_T_gB0cZ5HQ</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Kinch, Michael S.</creator><creator>Hoyer, Denton</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3939-3756</orcidid></search><sort><creationdate>20151001</creationdate><title>A history of drug development in four acts</title><author>Kinch, Michael S. ; Hoyer, Denton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-6c796f2067acc15a01dc7e3b556dc389b00cbae5581165a63663da5c4f62efe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Drug Approval - history</topic><topic>Drug Design</topic><topic>Drug Discovery - history</topic><topic>Drug Discovery - legislation & jurisprudence</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Legislation, Drug - history</topic><topic>United States</topic><topic>United States Food and Drug Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinch, Michael S.</creatorcontrib><creatorcontrib>Hoyer, Denton</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinch, Michael S.</au><au>Hoyer, Denton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A history of drug development in four acts</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>20</volume><issue>10</issue><spage>1163</spage><epage>1168</epage><pages>1163-1168</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>•The future of pharmaceutical discovery is unclear in light of unique trends in marketing and R&D allocations.•Slowing investment in early-stage discovery raises concerns about pipeline sustainability.•Decreasing NIH funding threatens the future of academia as a source of innovation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25908577</pmid><doi>10.1016/j.drudis.2015.04.003</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3939-3756</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-6446 |
| ispartof | Drug discovery today, 2015-10, Vol.20 (10), p.1163-1168 |
| issn | 1359-6446 1878-5832 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1723756359 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Drug Approval - history Drug Design Drug Discovery - history Drug Discovery - legislation & jurisprudence History, 20th Century History, 21st Century Humans Legislation, Drug - history United States United States Food and Drug Administration |
| title | A history of drug development in four acts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A11%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20history%20of%20drug%20development%20in%20four%20acts&rft.jtitle=Drug%20discovery%20today&rft.au=Kinch,%20Michael%20S.&rft.date=2015-10-01&rft.volume=20&rft.issue=10&rft.spage=1163&rft.epage=1168&rft.pages=1163-1168&rft.issn=1359-6446&rft.eissn=1878-5832&rft_id=info:doi/10.1016/j.drudis.2015.04.003&rft_dat=%3Cproquest_cross%3E1723756359%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1723756359&rft_id=info:pmid/25908577&rft_els_id=S1359644615001476&rfr_iscdi=true |