De novo FUS mutations are the most frequent genetic cause in early-onset German ALS patients

Abstract In amyotrophic lateral sclerosis (ALS) patients with known genetic cause, mutations in chromosome 9 open reading frame 72 ( C9orf72 ) and superoxide dismutase 1 ( SOD1 ) account for most familial and late-onset sporadic cases, whereas mutations in fused in sarcoma ( FUS ) can be identified...

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