RNA Folding and Misfolding of the Hammerhead Ribozyme

The hammerhead ribozyme undergoes a well-defined two-stage folding process induced by the sequential binding of two magnesium ions. These probably correspond to the formation of domain 2 (0−500 μM magnesium ions) and domain 1 (1−20 mM magnesium ions), respectively. In this study we have used fluores...

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Veröffentlicht in:	Biochemistry (Easton) 1999-03, Vol.38 (11), p.3345-3354
Hauptverfasser:	Bassi, Gurminder S, Møllegaard, Niels Erik, Murchie, Alastair I. H, Lilley, David M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - chemistry Deoxyguanosine - chemistry Energy Transfer Enzyme Activation - genetics Fluorescence Polarization Guanine - chemistry Hydrolysis Magnesium - chemistry Mutagenesis, Site-Directed Nucleic Acid Conformation Photochemistry RNA, Catalytic - antagonists & inhibitors RNA, Catalytic - chemistry RNA, Catalytic - genetics Spectrometry, Fluorescence Uracil - chemistry
Online-Zugang:	Volltext
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